The Interconnected Roles of TRIM21/Ro52 in Systemic Lupus Erythematosus, Primary Sjögren's Syndrome, Cancers, and Cancer Metabolism

Overview

Journal Cancer Cell Int

Publisher Biomed Central

Date 2023 Nov 23

PMID 37993883

Authors

Chueh-Hsuan Hsu

Yung-Luen Yu

Affiliations

Soon will be listed here.

Abstract

Protein tripartite motif-containing 21 (TRIM21/Ro52), an E3 ubiquitin ligase, is an essential regulator of innate immunity, and its dysregulation is closely associated with the development of autoimmune diseases, predominantly systemic lupus erythematosus (SLE) and primary Sjögren's syndrome (pSS). TRIM21 /Ro52 also features anti-cancer and carcinogenic functions according to different malignancies. The interconnected role of TRIM21/Ro52 in regulating autoimmunity and cell metabolism in autoimmune diseases and malignancies is implicated. In this review, we summarize current findings on how TRIM21/Ro52 affects inflammation and tumorigenesis, and investigate the relationship between TRIM21/Ro52 expression and the formation of lymphoma and breast cancer in SLE and pSS populations.

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