Down Syndrome in a New Era for Alzheimer Disease

Overview

Journal JAMA

Publisher American Medical Association

Specialty General Medicine

Date 2023 Nov 22

PMID 37991807

Authors

Michael S Rafii

Juan Fortea

Affiliations

Soon will be listed here.

Citing Articles

Decoding brain structure to stage Alzheimer's disease pathology in Down syndrome.

Kennedy J, Wisch J, Dincer A, Roman J, Gordon B, Handen B Alzheimers Dement. 2025; 21(2):e14519.

PMID: 39807622 PMC: 11848172. DOI: 10.1002/alz.14519.

The striatum is an early, accurate indicator of amyloid burden using [C]PiB in Down syndrome: comparison of two radiotracers.

McLachlan M, Bettcher B, McVea A, DiFillipo A, Zammit M, LeMerise L medRxiv. 2024; .

PMID: 39677434 PMC: 11643166. DOI: 10.1101/2024.12.04.24318526.

Comparing research attitudes in Down syndrome and non-Down syndrome research decision-makers.

Lu T, Campos P, Leader S, Lee X, Xu H, Doran E Alzheimers Dement (N Y). 2024; 10(3):e12478.

PMID: 39086735 PMC: 11289724. DOI: 10.1002/trc2.12478.

Amyloid-β peptide signature associated with cerebral amyloid angiopathy in familial Alzheimer's disease with APPdup and Down syndrome.

Kasri A, Camporesi E, Gkanatsiou E, Boluda S, Brinkmalm G, Stimmer L Acta Neuropathol. 2024; 148(1):8.

PMID: 39026031 PMC: 11258176. DOI: 10.1007/s00401-024-02756-4.

Assessing amyloid PET positivity and cognitive function in Down syndrome to guide clinical trials targeting amyloid.

Krasny S, Yan C, Hartley S, Handen B, Wisch J, Boehrwinkle A Alzheimers Dement. 2024; 20(8):5570-5577.

PMID: 38940611 PMC: 11350128. DOI: 10.1002/alz.14068.

References

Clift A, Coupland C, Keogh R, Hemingway H, Hippisley-Cox J . COVID-19 Mortality Risk in Down Syndrome: Results From a Cohort Study of 8 Million Adults. Ann Intern Med. 2020; 174(4):572-576. PMC: 7592804. DOI: 10.7326/M20-4986. View

Carmona-Iragui M, Balasa M, Benejam B, Alcolea D, Fernandez S, Videla L . Cerebral amyloid angiopathy in Down syndrome and sporadic and autosomal-dominant Alzheimer's disease. Alzheimers Dement. 2017; 13(11):1251-1260. PMC: 5660938. DOI: 10.1016/j.jalz.2017.03.007. View

Iulita M, Garzon Chavez D, Christensen M, Tamayo N, Plana-Ripoll O, Rasmussen S . Association of Alzheimer Disease With Life Expectancy in People With Down Syndrome. JAMA Netw Open. 2022; 5(5):e2212910. PMC: 9127560. DOI: 10.1001/jamanetworkopen.2022.12910. View

Fortea J, Zaman S, Hartley S, Rafii M, Head E, Carmona-Iragui M . Alzheimer's disease associated with Down syndrome: a genetic form of dementia. Lancet Neurol. 2021; 20(11):930-942. PMC: 9387748. DOI: 10.1016/S1474-4422(21)00245-3. View

Sims J, Zimmer J, Evans C, Lu M, Ardayfio P, Sparks J . Donanemab in Early Symptomatic Alzheimer Disease: The TRAILBLAZER-ALZ 2 Randomized Clinical Trial. JAMA. 2023; 330(6):512-527. PMC: 10352931. DOI: 10.1001/jama.2023.13239. View