The Characterization of CD8 T-cell Responses in COVID-19

Overview

Journal Emerg Microbes Infect

Specialty Infectious Diseases

Date 2023 Nov 22

PMID 37990907

Authors

Yuanting Yang

Heather Miller

Maria G Byazrova

Fabio Cndotti

Kamel Benlagha

Niels Olsen Saraiva Camara

Junming Shi

Huamei Forsman

Pamela Lee

Lu Yang

Alexander Filatov

Zhimin Zhai

Chaohong Liu

Affiliations

Soon will be listed here.

Abstract

This review gives an overview of the protective role of CD8 T cells in SARS-CoV-2 infection. The cross-reactive responses intermediated by CD8 T cells in unexposed cohorts are described. Additionally, the relevance of resident CD8 T cells in the upper and lower airway during infection and CD8 T-cell responses following vaccination are discussed, including recent worrisome breakthrough infections and variants of concerns (VOCs). Lastly, we explain the correlation between CD8 T cells and COVID-19 severity. This review aids in a deeper comprehension of the association between CD8 T cells and SARS-CoV-2 and broadens a vision for future exploration.

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