Development and Challenges of Cyclic Peptides for Immunomodulation

Overview

Journal Curr Protein Pept Sci

Publisher Bentham Science Publishers

Specialty Biochemistry

Date 2023 Nov 22

PMID 37990433

Authors

Xianqiong Jiang

Li Gao

Zhilong Li

Yan Shen

Zhi-Hua Lin

Affiliations

Soon will be listed here.

Abstract

Cyclic peptides are polypeptide chains formed by cyclic sequences of amide bonds between protein-derived or non-protein-derived amino acids. Compared to linear peptides, cyclic peptides offer several unique advantages, such as increased stability, stronger affinity, improved selectivity, and reduced toxicity. Cyclic peptide has been proved to have a promising application prospect in the medical field. In addition, this paper mainly describes that cyclic peptides play an important role in anti-cancer, anti-inflammatory, anti-virus, treatment of multiple sclerosis and membranous nephropathy through immunomodulation. In order to know more useful information about cyclic peptides in clinical research and drug application, this paper also summarizes cyclic peptides currently in the clinical trial stage and cyclic peptide drugs approved for marketing in the recent five years. Cyclic peptides have many advantages and great potential in treating various diseases, but there are still many challenges to be solved in the development process of cyclic peptides.

Citing Articles

Natural Cyclic Peptides: Synthetic Strategies and Biomedical Applications.

Buchanan D, Mori S, Chadli A, Panda S Biomedicines. 2025; 13(1).

PMID: 39857823 PMC: 11763372. DOI: 10.3390/biomedicines13010240.

References

Muttenthaler M, King G, Adams D, Alewood P . Trends in peptide drug discovery. Nat Rev Drug Discov. 2021; 20(4):309-325. DOI: 10.1038/s41573-020-00135-8. View

Abdalla M, McGaw L . Natural Cyclic Peptides as an Attractive Modality for Therapeutics: A Mini Review. Molecules. 2018; 23(8). PMC: 6222632. DOI: 10.3390/molecules23082080. View

Bellavita R, Maione A, Merlino F, Siciliano A, Dardano P, De Stefano L . Antifungal and Antibiofilm Activity of Cyclic Temporin L Peptide Analogues against Albicans and Non-Albicans Species. Pharmaceutics. 2022; 14(2). PMC: 8877061. DOI: 10.3390/pharmaceutics14020454. View

Bajraktari-Sylejmani G, von Linde T, Burhenne J, Haefeli W, Sauter M, Weiss J . Evaluation of PepT1 (SLC15A1) Substrate Characteristics of Therapeutic Cyclic Peptides. Pharmaceutics. 2022; 14(8). PMC: 9415731. DOI: 10.3390/pharmaceutics14081610. View

Horton D, Bourne G, Smythe M . Exploring privileged structures: the combinatorial synthesis of cyclic peptides. J Comput Aided Mol Des. 2002; 16(5-6):415-30. DOI: 10.1023/a:1020863921840. View

Furman O, Zaporozhets A, Tobi D, Bazylevich A, Firer M, Patsenker L . Novel Cyclic Peptides for Targeting EGFR and EGRvIII Mutation for Drug Delivery. Pharmaceutics. 2022; 14(7). PMC: 9318536. DOI: 10.3390/pharmaceutics14071505. View

Gallo M, Defaus S, Andreu D . Disrupting GPCR Complexes with Smart Drug-like Peptides. Pharmaceutics. 2022; 14(1). PMC: 8779866. DOI: 10.3390/pharmaceutics14010161. View

Jiang L, Huang P, Ren B, Song Z, Zhu G, He W . Antibacterial polyene-polyol macrolides and cyclic peptides from the marine-derived Streptomyces sp. MS110128. Appl Microbiol Biotechnol. 2021; 105(12):4975-4986. DOI: 10.1007/s00253-021-11226-w. View

Karim M, In Y, Zhou T, Harunari E, Oku N, Igarashi Y . Nyuzenamides A and B: Bicyclic Peptides with Antifungal and Cytotoxic Activity from a Marine-Derived sp. Org Lett. 2021; 23(6):2109-2113. DOI: 10.1021/acs.orglett.1c00210. View

10.

Muratspahic E, Tomasevic N, Nasrollahi-Shirazi S, Gattringer J, Emser F, Freissmuth M . Plant-Derived Cyclotides Modulate κ-Opioid Receptor Signaling. J Nat Prod. 2021; 84(8):2238-2248. PMC: 8406418. DOI: 10.1021/acs.jnatprod.1c00301. View

11.

Du Q, Huang Y, Bajpai A, Frosig-Jorgensen M, Zhao G, Craik D . Evaluation of the Aphrodisiac Activity of a Cyclotide Extract from . J Nat Prod. 2020; 83(12):3736-3743. DOI: 10.1021/acs.jnatprod.0c01045. View

12.

Fahradpour M, Keov P, Tognola C, Perez-Santamarina E, McCormick P, Ghassempour A . Cyclotides Isolated from an Ipecac Root Extract Antagonize the Corticotropin Releasing Factor Type 1 Receptor. Front Pharmacol. 2017; 8:616. PMC: 5627009. DOI: 10.3389/fphar.2017.00616. View

13.

Anastasiou E, Lorentz K, Stein G, Mitchell P . Prehistoric schistosomiasis parasite found in the Middle East. Lancet Infect Dis. 2014; 14(7):553-4. DOI: 10.1016/S1473-3099(14)70794-7. View

14.

Abdalla M . Three new cyclotetrapeptides isolated from Streptomyces sp. 447. Nat Prod Res. 2016; 31(9):1014-1021. DOI: 10.1080/14786419.2016.1263849. View

15.

Wyche T, Ruzzini A, Schwab L, Currie C, Clardy J . Tryptorubin A: A Polycyclic Peptide from a Fungus-Derived Streptomycete. J Am Chem Soc. 2017; 139(37):12899-12902. PMC: 5609116. DOI: 10.1021/jacs.7b06176. View

16.

Liang X, Nong X, Huang Z, Qi S . Antifungal and Antiviral Cyclic Peptides from the Deep-Sea-Derived Fungus Simplicillium obclavatum EIODSF 020. J Agric Food Chem. 2017; 65(25):5114-5121. DOI: 10.1021/acs.jafc.7b01238. View

17.

Zhou T, Katsuragawa M, Xing T, Fukaya K, Okuda T, Tokiwa T . Cyclopeptides from the Mushroom Pathogen Fungus . J Nat Prod. 2021; 84(2):327-338. DOI: 10.1021/acs.jnatprod.0c00980. View

18.

Takashina K, Katsuyama A, Kaguchi R, Yamamoto K, Sato T, Takahashi S . Solid-Phase Total Synthesis of Plusbacin A. Org Lett. 2022; 24(11):2253-2257. DOI: 10.1021/acs.orglett.2c00667. View

19.

Ullrich S, George J, Coram A, Morewood R, Nitsche C . Biocompatible and Selective Generation of Bicyclic Peptides. Angew Chem Int Ed Engl. 2022; 61(43):e202208400. DOI: 10.1002/anie.202208400. View

20.

Marciniak A, Pacini L, Papini A, Brasun J . Bicyclopeptides: a new class of ligands for Cu(II) ions. Dalton Trans. 2022; 51(35):13368-13375. DOI: 10.1039/d2dt01497a. View