Respiratory Syncytial Virus in Pediatric Patients with Severe Acute Respiratory Infections in Senegal: Findings from the 2022 Sentinel Surveillance Season

Overview

Journal Sci Rep

Specialty Science

Date 2023 Nov 22

PMID 37990112

Authors

Mamadou Malado Jallow

Moussa Moise Diagne

Samba Niang Sagne

Fatime Tall

Jean Baptisse Niokhor Diouf

Djibril Boiro

Marie Pedapa Mendy

Ndiende Koba Ndiaye

Davy Kiori

Sara Sy

Deborah Goudiaby

Cheikh Loucoubar

Gamou Fall

Mamadou Aliou Barry

Ndongo Dia

Affiliations

Soon will be listed here.

Abstract

In 2022, many regions around the world experienced a severe respiratory syncytial virus (RSV) epidemic with an earlier-than-usual start and increased numbers of paediatric patients in emergency departments. Here we carried out this study to describe the epidemiology and genetic characteristics of RSV infection in patients hospitalized with severe acute respiratory infections in 2022. Samples were tested for RSV by multiplex real time reverse transcription polymerase chain reaction. Subsequently, a subset of RSV positive samples was selected for NGS sequencing. RSV was detected in 16.04%, among which RSV-A was confirmed in 7.5% and RSV-B in 76.7%. RSV infection were more identified in infants aged ≤ 11 months (83.3%) and a shift in the circulation pattern was observed, with highest incidences between September-November. Phylogenetic analyses revealed that all RSV-A strains belonged to GA2.3.5 genotype and all RSV-B strains to GB5.0.5a genotype. Three putative N-glycosylation sites at amino acid positions 103, 135, 237 were predicted among RSV-A strains, while four N-linked glycosylation sites at positions 81, 86, 231 and 294 were identified in RSV-B strains. Globally, our findings reveal an exclusive co-circulation of two genetic lineages of RSV within the pediatric population in Senegal, especially in infants aged ≤ 11 months.

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