What Are the Roles of Oligodendrocyte Precursor Cells in Normal and Pathologic Conditions?

Overview

Journal Neurology

Specialty Neurology

Date 2023 Nov 20

PMID 37985182

Authors

Eduardo Benarroch

Affiliations

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References

Mount C, Monje M . Wrapped to Adapt: Experience-Dependent Myelination. Neuron. 2017; 95(4):743-756. PMC: 5667660. DOI: 10.1016/j.neuron.2017.07.009. View

Balia M, Benamer N, Angulo M . A specific GABAergic synapse onto oligodendrocyte precursors does not regulate cortical oligodendrogenesis. Glia. 2017; 65(11):1821-1832. DOI: 10.1002/glia.23197. View

Niu J, Tsai H, Hoi K, Huang N, Yu G, Kim K . Aberrant oligodendroglial-vascular interactions disrupt the blood-brain barrier, triggering CNS inflammation. Nat Neurosci. 2019; 22(5):709-718. PMC: 6486410. DOI: 10.1038/s41593-019-0369-4. View

Li T, Wang L, Ma T, Wang S, Niu J, Li H . Dynamic Calcium Release From Endoplasmic Reticulum Mediated by Ryanodine Receptor 3 Is Crucial for Oligodendroglial Differentiation. Front Mol Neurosci. 2018; 11:162. PMC: 5968115. DOI: 10.3389/fnmol.2018.00162. View

Pan L, Trimarco A, Zhang A, Fujimori K, Urade Y, Sun L . Oligodendrocyte-lineage cell exocytosis and L-type prostaglandin D synthase promote oligodendrocyte development and myelination. Elife. 2023; 12. PMC: 9946447. DOI: 10.7554/eLife.77441. View

Watzlawik J, Warrington A, Rodriguez M . PDGF is required for remyelination-promoting IgM stimulation of oligodendrocyte progenitor cell proliferation. PLoS One. 2013; 8(2):e55149. PMC: 3562326. DOI: 10.1371/journal.pone.0055149. View

Yi C, Verkhratsky A, Niu J . Pathological potential of oligodendrocyte precursor cells: terra incognita. Trends Neurosci. 2023; 46(7):581-596. DOI: 10.1016/j.tins.2023.04.003. View

Micu I, Plemel J, Caprariello A, Nave K, Stys P . Axo-myelinic neurotransmission: a novel mode of cell signalling in the central nervous system. Nat Rev Neurosci. 2017; 19(1):49-58. DOI: 10.1038/nrn.2017.128. View

Almeida R, Lyons D . On Myelinated Axon Plasticity and Neuronal Circuit Formation and Function. J Neurosci. 2017; 37(42):10023-10034. PMC: 6596541. DOI: 10.1523/JNEUROSCI.3185-16.2017. View

10.

Meyer N, Rinholm J . Mitochondria in Myelinating Oligodendrocytes: Slow and Out of Breath?. Metabolites. 2021; 11(6). PMC: 8226700. DOI: 10.3390/metabo11060359. View

11.

Zonouzi M, Scafidi J, Li P, McEllin B, Edwards J, Dupree J . GABAergic regulation of cerebellar NG2 cell development is altered in perinatal white matter injury. Nat Neurosci. 2015; 18(5):674-82. PMC: 4459267. DOI: 10.1038/nn.3990. View

12.

Smith M, Chamling X, Gill A, Martinez H, Li W, Fitzgerald K . Reactive Astrocytes Derived From Human Induced Pluripotent Stem Cells Suppress Oligodendrocyte Precursor Cell Differentiation. Front Mol Neurosci. 2022; 15:874299. PMC: 9120968. DOI: 10.3389/fnmol.2022.874299. View

13.

Volpe J . Brain injury in premature infants: a complex amalgam of destructive and developmental disturbances. Lancet Neurol. 2008; 8(1):110-24. PMC: 2707149. DOI: 10.1016/S1474-4422(08)70294-1. View

14.

Wolswijk G . Oligodendrocyte survival, loss and birth in lesions of chronic-stage multiple sclerosis. Brain. 1999; 123 ( Pt 1):105-15. DOI: 10.1093/brain/123.1.105. View

15.

Lin S, Huck J, Roberts J, Macklin W, Somogyi P, Bergles D . Climbing fiber innervation of NG2-expressing glia in the mammalian cerebellum. Neuron. 2005; 46(5):773-85. DOI: 10.1016/j.neuron.2005.04.025. View

16.

Hines J, Ravanelli A, Schwindt R, Scott E, Appel B . Neuronal activity biases axon selection for myelination in vivo. Nat Neurosci. 2015; 18(5):683-9. PMC: 4414883. DOI: 10.1038/nn.3992. View

17.

Dong Y, Zhang H, Li H, Liu P, Sui Y, Sun X . Association between Alzheimer's disease pathogenesis and early demyelination and oligodendrocyte dysfunction. Neural Regen Res. 2018; 13(5):908-914. PMC: 5998637. DOI: 10.4103/1673-5374.232486. View

18.

Alonso G . NG2 proteoglycan-expressing cells of the adult rat brain: possible involvement in the formation of glial scar astrocytes following stab wound. Glia. 2004; 49(3):318-38. DOI: 10.1002/glia.20121. View

19.

Balia M, Velez-Fort M, Passlick S, Schafer C, Audinat E, Steinhauser C . Postnatal down-regulation of the GABAA receptor γ2 subunit in neocortical NG2 cells accompanies synaptic-to-extrasynaptic switch in the GABAergic transmission mode. Cereb Cortex. 2013; 25(4):1114-23. DOI: 10.1093/cercor/bht309. View

20.

Singh J, Sharma K, Frost E, Pillai P . Role of PDGF-A-Activated ERK Signaling Mediated FAK-Paxillin Interaction in Oligodendrocyte Progenitor Cell Migration. J Mol Neurosci. 2019; 67(4):564-573. DOI: 10.1007/s12031-019-1260-1. View