The Link Between COVID-19 and Alzheimer Disease Through Neuroinflammation

Overview

Journal Clin Med Res

Specialty General Medicine

Date 2023 Nov 20

PMID 37985172

Authors

Ali Nouraeinejad

Affiliations

Soon will be listed here.

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References

Mun M, Kim J, Choi J, Jang W . Genetic polymorphisms of interleukin genes and the risk of Alzheimer's disease: An update meta-analysis. Meta Gene. 2016; 8:1-10. PMC: 4792847. DOI: 10.1016/j.mgene.2016.01.001. View

Nouraeinejad A . Brain fog as a Long-term Sequela of COVID-19. SN Compr Clin Med. 2022; 5(1):9. PMC: 9685075. DOI: 10.1007/s42399-022-01352-5. View

Ciaccio M, Lo Sasso B, Scazzone C, Gambino C, Ciaccio A, Bivona G . COVID-19 and Alzheimer's Disease. Brain Sci. 2021; 11(3). PMC: 7997244. DOI: 10.3390/brainsci11030305. View

Santa Cruz A, Mendes-Frias A, Oliveira A, Dias L, Matos A, Carvalho A . Interleukin-6 Is a Biomarker for the Development of Fatal Severe Acute Respiratory Syndrome Coronavirus 2 Pneumonia. Front Immunol. 2021; 12:613422. PMC: 7930905. DOI: 10.3389/fimmu.2021.613422. View

Chen X, Zhao B, Qu Y, Chen Y, Xiong J, Feng Y . Detectable Serum Severe Acute Respiratory Syndrome Coronavirus 2 Viral Load (RNAemia) Is Closely Correlated With Drastically Elevated Interleukin 6 Level in Critically Ill Patients With Coronavirus Disease 2019. Clin Infect Dis. 2020; 71(8):1937-1942. PMC: 7184354. DOI: 10.1093/cid/ciaa449. View

Chen Y, Wang S, Weng I, Hong M, Lo T, Jan J . Galectin-3 Enhances Avian H5N1 Influenza A Virus-Induced Pulmonary Inflammation by Promoting NLRP3 Inflammasome Activation. Am J Pathol. 2018; 188(4):1031-1042. DOI: 10.1016/j.ajpath.2017.12.014. View

Heneka M, Carson M, El Khoury J, Landreth G, Brosseron F, Feinstein D . Neuroinflammation in Alzheimer's disease. Lancet Neurol. 2015; 14(4):388-405. PMC: 5909703. DOI: 10.1016/S1474-4422(15)70016-5. View

Shah T, Zabaneh D, Gaunt T, Swerdlow D, Shah S, Talmud P . Gene-centric analysis identifies variants associated with interleukin-6 levels and shared pathways with other inflammation markers. Circ Cardiovasc Genet. 2013; 6(2):163-70. DOI: 10.1161/CIRCGENETICS.112.964254. View

Mohammadi S, Moosaie F, Aarabi M . Understanding the Immunologic Characteristics of Neurologic Manifestations of SARS-CoV-2 and Potential Immunological Mechanisms. Mol Neurobiol. 2020; 57(12):5263-5275. PMC: 7458880. DOI: 10.1007/s12035-020-02094-y. View

10.

Cojocaru I, Cojocaru M, Miu G, Sapira V . Study of interleukin-6 production in Alzheimer's disease. Rom J Intern Med. 2011; 49(1):55-8. View

11.

Siew J, Chen H, Chen H, Chen H, Chen C, Soong B . Galectin-3 is required for the microglia-mediated brain inflammation in a model of Huntington's disease. Nat Commun. 2019; 10(1):3473. PMC: 6677843. DOI: 10.1038/s41467-019-11441-0. View

12.

Rahman M, Islam K, Rahman S, Alamin M . Neurobiochemical Cross-talk Between COVID-19 and Alzheimer's Disease. Mol Neurobiol. 2020; 58(3):1017-1023. PMC: 7571527. DOI: 10.1007/s12035-020-02177-w. View

13.

Cavalli G, Luca G, Campochiaro C, Della-Torre E, Ripa M, Canetti D . Interleukin-1 blockade with high-dose anakinra in patients with COVID-19, acute respiratory distress syndrome, and hyperinflammation: a retrospective cohort study. Lancet Rheumatol. 2020; 2(6):e325-e331. PMC: 7252085. DOI: 10.1016/S2665-9913(20)30127-2. View

14.

Schirinzi T, Landi D, Liguori C . COVID-19: dealing with a potential risk factor for chronic neurological disorders. J Neurol. 2020; 268(4):1171-1178. PMC: 7450256. DOI: 10.1007/s00415-020-10131-y. View

15.

Golzari-Sorkheh M, Brown C, Weaver D, Reed M . The NLRP3 Inflammasome in the Pathogenesis and Treatment of Alzheimer's Disease. J Alzheimers Dis. 2021; 84(2):579-598. DOI: 10.3233/JAD-210660. View

16.

Akiyama H, Barger S, Barnum S, Bradt B, Bauer J, Cole G . Inflammation and Alzheimer's disease. Neurobiol Aging. 2000; 21(3):383-421. PMC: 3887148. DOI: 10.1016/s0197-4580(00)00124-x. View

17.

Reynolds J, Mahajan S . SARS-COV2 Alters Blood Brain Barrier Integrity Contributing to Neuro-Inflammation. J Neuroimmune Pharmacol. 2021; 16(1):4-6. PMC: 7786155. DOI: 10.1007/s11481-020-09975-y. View

18.

Cauchois R, Koubi M, Delarbre D, Manet C, Carvelli J, Blasco V . Early IL-1 receptor blockade in severe inflammatory respiratory failure complicating COVID-19. Proc Natl Acad Sci U S A. 2020; 117(32):18951-18953. PMC: 7430998. DOI: 10.1073/pnas.2009017117. View

19.

Wang X, Zhang S, Lin F, Chu W, Yue S . Elevated Galectin-3 Levels in the Serum of Patients With Alzheimer's Disease. Am J Alzheimers Dis Other Demen. 2013; 30(8):729-32. PMC: 10852776. DOI: 10.1177/1533317513495107. View

20.

Nouraeinejad A . Visuospatial impairment is of concern in patients with COVID-19. Int J Neurosci. 2022; 134(7):810-811. DOI: 10.1080/00207454.2022.2145474. View