Application of Surface-layer Matrix-assisted Laser Desorption/ionization Mass Spectrometry Imaging to Pharmaceutical-loaded Poly(ester Urea) Films

Overview

Journal Anal Chim Acta

Publisher Elsevier

Specialty Chemistry

Date 2023 Nov 17

PMID 37977787

Authors

Kayla Williams-Pavlantos

Natasha C Brigham-Stinson

Matthew L Becker

Chrys Wesdemiotis

Affiliations

Soon will be listed here.

Abstract

Polymer thin films are often used in transdermal patches as a method of continuous drug administration for patients with chronic illness. Understanding the drug segregation and distribution within these films is important for monitoring proper drug release over time. Surface-layer matrix-assisted laser desorption/ionization mass spectrometry imaging (SL-MALDI-MSI) is a unique analytical technique that provides an optical representation of chemical compositions that exist at the surface of polymeric materials. Solvent-free sublimation is employed for application of matrix to the sample surface, so that only molecules in direct contact with the matrix layer are detected. Here, these methodologies are utilized to visualize variations in drug concentration at both the air and substrate interface in pharmaceutical-loaded polymer films.

References

Crecelius A, Alexandrov T, Schubert U . Application of matrix-assisted laser desorption/ionization mass spectrometric imaging to monitor surface changes of UV-irradiated poly(styrene) films. Rapid Commun Mass Spectrom. 2011; 25(19):2809-14. DOI: 10.1002/rcm.5164. View

Dautremont E, Ebramzadeh E, Beck J, Bowen R, Sangiorgio S . Opioid Prescription and Usage in Adolescents Undergoing Orthopaedic Surgery in the United States: A Systematic Review. JBJS Rev. 2017; 5(8):e5. DOI: 10.2106/JBJS.RVW.16.00093. View

Wang S, Li X, Agapov R, Wesdemiotis C, Foster M . Probing Surface Concentration of Cyclic/Linear Blend Films Using Surface Layer MALDI-TOF Mass Spectrometry. ACS Macro Lett. 2022; 1(8):1024-1027. DOI: 10.1021/mz300271w. View

Khatib-Shahidi S, Andersson M, Herman J, Gillespie T, Caprioli R . Direct molecular analysis of whole-body animal tissue sections by imaging MALDI mass spectrometry. Anal Chem. 2006; 78(18):6448-56. DOI: 10.1021/ac060788p. View

Tobias F, Hummon A . Considerations for MALDI-Based Quantitative Mass Spectrometry Imaging Studies. J Proteome Res. 2020; 19(9):3620-3630. PMC: 8221076. DOI: 10.1021/acs.jproteome.0c00443. View

Hankin J, Barkley R, Murphy R . Sublimation as a method of matrix application for mass spectrometric imaging. J Am Soc Mass Spectrom. 2007; 18(9):1646-52. PMC: 2042488. DOI: 10.1016/j.jasms.2007.06.010. View

Norris J, Caprioli R . Analysis of tissue specimens by matrix-assisted laser desorption/ionization imaging mass spectrometry in biological and clinical research. Chem Rev. 2013; 113(4):2309-42. PMC: 3624074. DOI: 10.1021/cr3004295. View

Hojsted J, Sjogren P . Addiction to opioids in chronic pain patients: a literature review. Eur J Pain. 2006; 11(5):490-518. DOI: 10.1016/j.ejpain.2006.08.004. View

Wesdemiotis C, Williams-Pavlantos K, Keating A, McGee A, Bochenek C . Mass spectrometry of polymers: A tutorial review. Mass Spectrom Rev. 2023; 43(3):427-476. DOI: 10.1002/mas.21844. View

10.

Madler S, Boeri Erba E, Zenobi R . MALDI-ToF mass spectrometry for studying noncovalent complexes of biomolecules. Top Curr Chem. 2012; 331:1-36. DOI: 10.1007/128_2011_311. View

11.

Ren S, Guo Y . Oxidized carbon nanotubes as matrix for matrix-assisted laser desorption/ionization time-of-flight mass spectrometric analysis of biomolecules. Rapid Commun Mass Spectrom. 2004; 19(2):255-60. DOI: 10.1002/rcm.1779. View

12.

Hill J, Endres K, Meyerhofer J, He Q, Wesdemiotis C, Foster M . Subtle End Group Functionalization of Polymer Chains Drives Surface Depletion of Entire Polymer Chains. ACS Macro Lett. 2022; 7(7):795-800. DOI: 10.1021/acsmacrolett.8b00394. View

13.

Endres K, Hill J, Lu K, Foster M, Wesdemiotis C . Surface Layer Matrix-Assisted Laser Desorption Ionization Mass Spectrometry Imaging: A Surface Imaging Technique for the Molecular-Level Analysis of Synthetic Material Surfaces. Anal Chem. 2018; 90(22):13427-13433. DOI: 10.1021/acs.analchem.8b03238. View

14.

Liechty W, Kryscio D, Slaughter B, Peppas N . Polymers for drug delivery systems. Annu Rev Chem Biomol Eng. 2012; 1:149-73. PMC: 3438887. DOI: 10.1146/annurev-chembioeng-073009-100847. View

15.

Francese S, Bradshaw R, Ferguson L, Wolstenholme R, Clench M, Bleay S . Beyond the ridge pattern: multi-informative analysis of latent fingermarks by MALDI mass spectrometry. Analyst. 2013; 138(15):4215-28. DOI: 10.1039/c3an36896c. View

16.

Leppert W, Malec-Milewska M, Zajaczkowska R, Wordliczek J . Transdermal and Topical Drug Administration in the Treatment of Pain. Molecules. 2018; 23(3). PMC: 6017304. DOI: 10.3390/molecules23030681. View

17.

Schwamborn K, Krieg R, Reska M, Jakse G, Knuechel R, Wellmann A . Identifying prostate carcinoma by MALDI-Imaging. Int J Mol Med. 2007; 20(2):155-9. View

18.

Krueger K, Terne C, Werner C, Freudenberg U, Jankowski V, Zidek W . Characterization of polymer membranes by MALDI mass-spectrometric imaging techniques. Anal Chem. 2013; 85(10):4998-5004. DOI: 10.1021/ac4002063. View

19.

Hill J, Endres K, Mahmoudi P, Matsen M, Wesdemiotis C, Foster M . Detection of Surface Enrichment Driven by Molecular Weight Disparity in Virtually Monodisperse Polymers. ACS Macro Lett. 2022; 7(4):487-492. DOI: 10.1021/acsmacrolett.7b00993. View

20.

Feinberg A, Chesney T, Srikandarajah S, Acuna S, McLeod R . Opioid Use After Discharge in Postoperative Patients: A Systematic Review. Ann Surg. 2017; 267(6):1056-1062. DOI: 10.1097/SLA.0000000000002591. View