Association of Nonalcoholic Fatty Liver Disease with the Different Types of Dietary Carbohydrates: a Cross-sectional Study

Overview

Journal J Diabetes Metab Disord

Specialty Endocrinology

Date 2023 Nov 17

PMID 37975105

Authors

Maryam Afsharfar

Zahra Salimi

Bahareh Aminnezhad Kavkani

Soheila Shekari

Saheb Abbastorki

Nazanin Majidi

Maryam Gholamalizadeh

Alireza Mosavi Jarrahi

Azadeh Hajipour

Hanieh Shafaei

Saeid Doaei

Affiliations

Soon will be listed here.

Abstract

Background: Many factors like sedentary lifestyle, metabolic syndrome, and obesity are involved in the increased prevalence of nonalcoholic fatty liver disease (NAFLD). Dietary consumption of carbohydrates may has a role in the risk of NAFLD. This study aimed to investigate the association of NAFLD with the different types of dietary carbohydrates.

Methods: This cross-sectional study was carried out on 4200 participants including 660 patients with NAFLD and 3540 helathy individuals without NAFLD ages 35 to 70 in sabzevar, Iran. Data on socio-deomgraphic status, anthropomrtric measurments, blood tests, and dietary intake of different types of dietary carbohydrates was collected.

Results: The patients with NAFLD had a significantly higher dietary intake of glucose (29.38 ± 18.29 vs. 27.42 ± 15.96 g/d, P = 0.01) and fructose (33.99 ± 20.19 vs. 31.95 ± 18.34 g/d, P = 0.01) compared to the healthy people. A positive association was observed between NAFLD with the total intake of carbohydrates after adjustment for age, sex, and BMI (OR: 1.001, CI 95%: 1-1.002, P = 0.04) The association remained significant after further adjustments for for education level, marital status, physical activity, smoking, and drinking alcohol (Model 2) and after additional adjustments for calorie intake (Model 3).

Conclusions: This study showed a positive association between total dietary carbohydrate and NAFLD. In particular, the amount of dietary of carbohydrates (regardless of the type of carbohydrate) may worsen NAFLD. Further longitudinal studies are warranted.

Citing Articles

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PMID: 39064665 PMC: 11279539. DOI: 10.3390/nu16142220.

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