Female Infertility and Dietary Antioxidant Index (DAI); a Case-control Study

Overview

Journal BMC Womens Health

Publisher Biomed Central

Specialty Gynecology & Obstetrics

Date 2023 Nov 17

PMID 37974175

Authors

Roya Kabodmehri

Fatemeh Sadat Hashemi Javaheri

Farkhondeh Alami

Zahra Mahmoudi

Arezoo Amjadi

Zahra Saeedirad

Saeed Omidi

Shiva Sadeghi

Mohadeseh Sadat Mousavi Hoseini

Zahra Mohamadiyan

Zahra Salimi

Hanieh Shafaei

Reyhaneh Rasekhmagham

Seyedeh Hajar Sharami

Maryam Karimian

Hoora Karimi

Saeid Doaei

Affiliations

Soon will be listed here.

Abstract

Background: Adequate intake of natural antioxidants may improve female fertility. The aim of this study was to examine the link between female infertility and dietary antioxidant index (DAI).

Methods: This case-control study was conducted on 125 women with recently diagnosis of reduced ovarian reserves (AMH < 1.1) as the case group and 125 women with normal ovarian reserve as the control group in Rasht, Iran. The amount of food intake was assessed using the food frequency questionnaire (FFQ) and the DAI was calculated to estimate the antioxidant capacity of the diet.

Results: Regarding dietary intake, the infertile women had a lower intake of potassium (2789.25 ± 777 vs. 2593.68 ± 443 mg/d, P = 0.02), magnesium (204.12 ± 66 vs. 189.73 ± 34 mg/d, P = 0.03), copper (0.93 ± 0.40 vs. 0.82 ± 0.20 mg/d, P < 0.01), vitamin C (133.99 ± 46 vs. 122.62 ± 24 mg/d, P = 0.02), and fiber (14.53 ± 3 vs. 13.44 ± 2 g/d, P < 0.05), and a higher intake of cholesterol (205.61 ± 58 vs. 227.02 ± 46 mg/d, P < 0.01) than the control group (All P < 0.05). The DAI was negatively associated with infertility (OR: 0.94, CI 95%: 0.88-0.97, P = 0.03). The association remained significant after adjustments for age, BMI, the underlying diseases, fertility frequency, IVF failure, and calorie intake.

Conclusion: Following an antioxidant-rich diet may reduce the risk of infertility. More longitudinal studies are warranted to confirm these results and discover the underlying mechanisms.

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References

Yeh J, Bowman M, Browne R, Chen N . Reproductive aging results in a reconfigured ovarian antioxidant defense profile in rats. Fertil Steril. 2005; 84 Suppl 2:1109-13. DOI: 10.1016/j.fertnstert.2005.02.054. View

Iavarone I, Greco P, La Verde M, Morlando M, Torella M, De Franciscis P . Correlations between Gut Microbial Composition, Pathophysiological and Surgical Aspects in Endometriosis: A Review of the Literature. Medicina (Kaunas). 2023; 59(2). PMC: 9962646. DOI: 10.3390/medicina59020347. View

Cicek N, Eryilmaz O, Sarikaya E, Gulerman C, Genc Y . Vitamin E effect on controlled ovarian stimulation of unexplained infertile women. J Assist Reprod Genet. 2012; 29(4):325-8. PMC: 3309992. DOI: 10.1007/s10815-012-9714-1. View

Nadjarzadeh A, Mehrsai A, Mostafavi E, Gohari M, Shidfar F . The association between dietary antioxidant intake and semen quality in infertile men. Med J Islam Repub Iran. 2014; 27(4):204-9. PMC: 4011410. View

Wright M, Mayne S, Stolzenberg-Solomon R, Li Z, Pietinen P, Taylor P . Development of a comprehensive dietary antioxidant index and application to lung cancer risk in a cohort of male smokers. Am J Epidemiol. 2004; 160(1):68-76. DOI: 10.1093/aje/kwh173. View

Fainberg J, Kashanian J . Recent advances in understanding and managing male infertility. F1000Res. 2019; 8. PMC: 6524745. DOI: 10.12688/f1000research.17076.1. View

Wang Y, Sharma R, Falcone T, Goldberg J, Agarwal A . Importance of reactive oxygen species in the peritoneal fluid of women with endometriosis or idiopathic infertility. Fertil Steril. 1997; 68(5):826-30. DOI: 10.1016/s0015-0282(97)00343-9. View

Grieger J, Grzeskowiak L, Wilson R, Bianco-Miotto T, Leemaqz S, Jankovic-Karasoulos T . Maternal Selenium, Copper and Zinc Concentrations in Early Pregnancy, and the Association with Fertility. Nutrients. 2019; 11(7). PMC: 6683068. DOI: 10.3390/nu11071609. View

Symonds D, Merchenthaler I, Flaws J . Methoxychlor and estradiol induce oxidative stress DNA damage in the mouse ovarian surface epithelium. Toxicol Sci. 2008; 105(1):182-7. PMC: 2734300. DOI: 10.1093/toxsci/kfn100. View

10.

Wang L, Tang J, Wang L, Tan F, Song H, Zhou J . Oxidative stress in oocyte aging and female reproduction. J Cell Physiol. 2021; 236(12):7966-7983. DOI: 10.1002/jcp.30468. View

11.

Elomda A, Saad M, Saeed A, Elsayed A, Abass A, Safaa H . Antioxidant and developmental capacity of retinol on the in vitro culture of rabbit embryos. Zygote. 2018; 26(4):326-332. DOI: 10.1017/S0967199418000308. View

12.

Ebrahimi Z, Masoodi M, Aslani Z, Naghshi S, Khalighi Sikaroudi M, Shidfar F . Association between dietary antioxidant index and risk of Helicobacter pylori infection among adults: a case-control study. BMC Gastroenterol. 2022; 22(1):413. PMC: 9450302. DOI: 10.1186/s12876-022-02488-3. View

13.

Vahid F, Rahmani D, Hekmatdoost A . The association between dietary antioxidant index (DAI) and nonalcoholic fatty liver disease (NAFLD) onset; new findings from an incident case-control study. Clin Nutr ESPEN. 2021; 41:360-364. DOI: 10.1016/j.clnesp.2020.10.020. View

14.

Sahin K, Orhan C, Kucuk O, Tuzcu M, Sahin N, Ozercan I . Effects of magnesium picolinate, zinc picolinate, and selenomethionine co-supplementation on reproductive hormones, and glucose and lipid metabolism-related protein expressions in male rats fed a high-fat diet. Food Chem (Oxf). 2022; 4:100081. PMC: 8991512. DOI: 10.1016/j.fochms.2022.100081. View

15.

Ruder E, Hartman T, Reindollar R, Goldman M . Female dietary antioxidant intake and time to pregnancy among couples treated for unexplained infertility. Fertil Steril. 2013; 101(3):759-66. PMC: 3943921. DOI: 10.1016/j.fertnstert.2013.11.008. View

16.

Westphal L, Polan M, Trant A, Mooney S . A nutritional supplement for improving fertility in women: a pilot study. J Reprod Med. 2004; 49(4):289-93. View

17.

Farsinejad-Marj M, Azadbakht L, Mardanian F, Saneei P, Esmaillzadeh A . Clinical and Metabolic Responses to Magnesium Supplementation in Women with Polycystic Ovary Syndrome. Biol Trace Elem Res. 2020; 196(2):349-358. DOI: 10.1007/s12011-019-01923-z. View

18.

Bhardwaj J, Panchal H, Saraf P . Ameliorating Effects of Natural Antioxidant Compounds on Female Infertility: a Review. Reprod Sci. 2020; 28(5):1227-1256. DOI: 10.1007/s43032-020-00312-5. View

19.

Henkel R, Sandhu I, Agarwal A . The excessive use of antioxidant therapy: A possible cause of male infertility?. Andrologia. 2018; 51(1):e13162. DOI: 10.1111/and.13162. View

20.

Bellver J, Donnez J . Introduction: Infertility etiology and offspring health. Fertil Steril. 2019; 111(6):1033-1035. DOI: 10.1016/j.fertnstert.2019.04.043. View