Cytoplasmic Zoning by Protein Phase Transition After Membrane Permeabilization

Overview

Journal J Biochem

Publisher Oxford University Press

Specialty Biochemistry

Date 2023 Nov 16

PMID 37972304

Authors

Shinju Sugiyama

Kojiro Suda

Keiko Kono

Affiliations

Soon will be listed here.

Abstract

Biological membranes, including plasma membrane (PM) and organelle membranes, restrict the flux of ions, molecules and organelles. However, the barrier function of biological membranes is frequently compromised by various perturbations, including physical membrane damage and protein- or chemical-induced pore formation. Recent evidence suggests that, upon PM damage, protein gelation and solid condensation are utilized to restrict ion/molecule/organelle flux across the damaged membranes by zoning the cytoplasm. In addition, membrane permeabilization dramatically alters intramembrane and extramembrane ion/molecule concentrations via the flux across the permeabilized membrane. The changes in ion/molecule concentration and their downstream pathways induce protein phase transition to form zones for biological processes or protein sequestration. Here, we review the mechanisms and functions of protein phase transition after biological membrane permeabilization.

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