What Should Be the Future Direction of Development in the Field of Prostate Cancer with Lung Metastasis?

Overview

Journal World J Clin Oncol

Publisher Baishideng Publishing Group

Specialty Oncology

Date 2023 Nov 16

PMID 37970109

Authors

Zhi-Guang Huang

Yi Chen

Tong Wu

Bin-Tong Yin

Xiao Feng

Sheng-Hua Li

Dong-Ming Li

Gang Chen

Ji-Wen Cheng

Juan He

Affiliations

Soon will be listed here.

Abstract

Background: Since the start of the 21 century, prostate cancer with lung metastasis (PCLM) has accumulated significant scientific research output. However, a systematic knowledge framework for PCLM is still lacking.

Aim: To reconstruct the global knowledge system in the field of PCLM, sort out hot research directions, and provide reference for the clinical and mechanism research of PCLM.

Methods: We retrieved 280 high-quality papers from the Web of Science Core Collection and conducted a bibliometric analysis of keywords, publication volume, and citation frequency. Additionally, we selected differentially expressed genes from global high-throughput datasets and performed enrichment analysis and protein-protein interaction analysis to further summarize and explore the mechanisms of PCLM.

Results: PCLM has received extensive attention over the past 22 years, but there is an uneven spatial distribution in PCLM research. In the clinical aspect, the treatment of PCLM is mainly based on chemotherapy and immunotherapy, while diagnosis relies on methods such as prostate-specific membrane antigen positron emission tomography/computed tomography. In the basic research aspect, the focus is on cell adhesion molecules and signal transducer and activator of transcription 3, among others. Traditional treatments, such as chemotherapy, remain the mainstay of PCLM treatment, while novel approaches such as immunotherapy have limited effectiveness in PCLM. This study reveals for the first time that pathways related to coronavirus disease 2019, cytokine-cytokine receptor interaction, and ribosome are closely associated with PCLM.

Conclusion: Future research should focus on exploring and enhancing mechanisms such as cytokine-cytokine receptor interaction and ribosome and improve existing mechanisms like cadherin binding and cell adhesion molecules.

References

Shi Y, Wei W, Li L, Wei Q, Jiang F, Xia G . The global status of research in breast cancer liver metastasis: a bibliometric and visualized analysis. Bioengineered. 2021; 12(2):12246-12262. PMC: 8810156. DOI: 10.1080/21655979.2021.2006552. View

Caristo J, Tian D, Yan T . Pulmonary metastasectomy: a cross sectional survey. J Thorac Dis. 2018; 10(6):3757-3766. PMC: 6051868. DOI: 10.21037/jtd.2018.05.45. View

Ragavi R, Muthukumaran P, Nandagopal S, Ahirwar D, Tomo S, Misra S . Epigenetics regulation of prostate cancer: Biomarker and therapeutic potential. Urol Oncol. 2023; 41(8):340-353. DOI: 10.1016/j.urolonc.2023.03.005. View

Pan C, Qin H, Yan M, Qiu X, Gong W, Luo W . Environmental microcystin exposure triggers the poor prognosis of prostate cancer: Evidence from case-control, animal, and in vitro studies. J Environ Sci (China). 2022; 127:69-81. DOI: 10.1016/j.jes.2022.05.051. View

Grosse Hokamp N, Kobe C, Linzenich E, Maintz D, Drzezga A . Solitary PSMA-Positive Pulmonary Metastasis in Biochemical Relapse of Prostate Cancer. Clin Nucl Med. 2017; 42(5):406-407. DOI: 10.1097/RLU.0000000000001582. View

de Scordilli M, Michelotti A, Bertoli E, De Carlo E, Del Conte A, Bearz A . Targeted Therapy and Immunotherapy in Early-Stage Non-Small Cell Lung Cancer: Current Evidence and Ongoing Trials. Int J Mol Sci. 2022; 23(13). PMC: 9266864. DOI: 10.3390/ijms23137222. View

Sholklapper T, Ballon J, Sayegh A, La Riva A, Perez L, Huang S . Bibliometric analysis of academic journal recommendations and requirements for surgical and anesthesiologic adverse events reporting. Int J Surg. 2023; 109(5):1489-1496. PMC: 10389352. DOI: 10.1097/JS9.0000000000000323. View

Nakashima H, Takatsu T, Imai R . Radiation-induced osteosarcoma in the pubic bone after proton radiotherapy for prostate cancer: a case report. J Rural Med. 2022; 17(2):94-100. PMC: 8984621. DOI: 10.2185/jrm.2021-047. View

Yamazaki H, Iwasaki H, Masudo K, Toda S, Matsui A, Rino Y . Prognostic significance of lung metastasis-related finding in lenvatinib treatment for differentiated thyroid cancer. Endocrine. 2022; 78(3):543-551. DOI: 10.1007/s12020-022-03183-9. View

10.

Lu X, Wu X, Jing L, Tao L, Zhang Y, Huang R . Network Pharmacology Analysis and Experiments Validation of the Inhibitory Effect of JianPi Fu Recipe on Colorectal Cancer LoVo Cells Metastasis and Growth. Evid Based Complement Alternat Med. 2020; 2020:4517483. PMC: 7399765. DOI: 10.1155/2020/4517483. View

11.

Esposito M, Ganesan S, Kang Y . Emerging strategies for treating metastasis. Nat Cancer. 2021; 2(3):258-270. PMC: 8064405. DOI: 10.1038/s43018-021-00181-0. View

12.

Kosaka T, Hongo H, Aimono E, Matsumoto K, Hayashida T, Mikami S . A first Japanese case of neuroendocrine prostate cancer accompanied by lung and brain metastasis with somatic and germline BRCA2 mutation. Pathol Int. 2019; 69(12):715-720. PMC: 6972566. DOI: 10.1111/pin.12860. View

13.

Gao Y, Yao A, Zhang W, Lu S, Yu Y, Deng L . Human mesenchymal stem cells overexpressing pigment epithelium-derived factor inhibit hepatocellular carcinoma in nude mice. Oncogene. 2010; 29(19):2784-94. DOI: 10.1038/onc.2010.38. View

14.

Baciarello G, Sternberg C . Treatment of metastatic castration-resistant prostate cancer (mCRPC) with enzalutamide. Crit Rev Oncol Hematol. 2016; 106:14-24. DOI: 10.1016/j.critrevonc.2016.07.005. View

15.

Mosca A, Mantica G, Giavarra M, Perrone V, De Marchi L, Gennari A . Curative Lung Metastasectomy Without Concomitant Androgen Deprivation Therapy in Oligometastatic Castration-resistant Prostate Cancer: A Case Report and Review of the Literature. Clin Genitourin Cancer. 2020; 18(3):e295-e299. DOI: 10.1016/j.clgc.2019.11.018. View

16.

He C, Hua X, Sun S, Li S, Wang J, Huang X . Integrated Bioinformatic Analysis of SARS-CoV-2 Infection Related Genes ACE2, BSG and TMPRSS2 in Aerodigestive Cancers. J Inflamm Res. 2021; 14:791-802. PMC: 7956868. DOI: 10.2147/JIR.S300127. View

17.

Izawa M, Kosaka T, Nakamura K, Oba J, Hishida T, Hongo H . Pulmonary metastasis secondary to abiraterone-resistant prostate cancer with homozygous deletions of BRCA2: First Japanese case. IJU Case Rep. 2021; 4(1):14-17. PMC: 7784740. DOI: 10.1002/iju5.12224. View

18.

Perez P, Hope T, Behr S, van Zante A, Small E, Flavell R . Intertumoral Heterogeneity of 18F-FDG and 68Ga-PSMA Uptake in Prostate Cancer Pulmonary Metastases. Clin Nucl Med. 2018; 44(1):e28-e32. DOI: 10.1097/RLU.0000000000002367. View

19.

HESS W, Marggraf G, REIDEMEISTER C . [Pulmonary artery rupture caused by a Swan-Ganz catheter during heart surgery. A successful therapeutic procedure]. Anaesthesist. 1988; 37(7):446-9. View

20.

Xing Z, Li S, Xing J, Yu G, Wang G, Liu Z . Silencing of LINC01963 enhances the chemosensitivity of prostate cancer cells to docetaxel by targeting the miR-216b-5p/TrkB axis. Lab Invest. 2022; 102(6):602-612. PMC: 9162921. DOI: 10.1038/s41374-022-00736-4. View