Organ-On-A-Chip: An Emerging Research Platform

Overview

Journal Organogenesis

Specialties Anatomy & Histology
Biology
Biotechnology

Date 2023 Nov 15

PMID 37965897

Authors

Nithin R

Ayushi Aggarwal

Anne Boyina Sravani

Pooja Mallya

Shaila Lewis

Affiliations

Soon will be listed here.

Abstract

In drug development, conventional preclinical and clinical testing stages rely on cell cultures and animal experiments, but these methods may fall short of fully representing human biology. To overcome this limitation, the emergence of organ-on-a-chip (OOC) technology has sparked interest as a transformative approach in drug testing research. By closely replicating human organ responses to external signals, OOC devices hold immense potential in revolutionizing drug efficacy and safety predictions. This review focuses on the advancements, applications, and prospects of OOC devices in drug testing. Based on the latest advances in the field of OOC systems and their clinical applications, this review reflects the effectiveness of OOC devices in replacing human volunteers in certain clinical studies. This review underscores the critical role of OOC technology in transforming drug testing methodologies.

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