Locomotor and Respiratory Muscle Abnormalities in HFrEF and HFpEF

Overview

Journal Front Cardiovasc Med

Specialty Cardiology & Vascular Diseases

Date 2023 Nov 15

PMID 37965088

Authors

Norman Mangner

Ephraim B Winzer

Axel Linke

Volker Adams

Affiliations

Soon will be listed here.

Abstract

Heart failure (HF) is a chronic and progressive syndrome affecting worldwide billions of patients. Exercise intolerance and early fatigue are hallmarks of HF patients either with a reduced (HFrEF) or a preserved (HFpEF) ejection fraction. Alterations of the skeletal muscle contribute to exercise intolerance in HF. This review will provide a contemporary summary of the clinical and molecular alterations currently known to occur in the skeletal muscles of both HFrEF and HFpEF, and thereby differentiate the effects on locomotor and respiratory muscles, in particular the diaphragm. Moreover, current and future therapeutic options to address skeletal muscle weakness will be discussed focusing mainly on the effects of exercise training.

Citing Articles

Post-Myocardial Infarction Rehabilitation: The Absence in the Rehabilitation Process of the Diaphragm Muscle.

Bordoni B, Mapelli L, Toccafondi A, Di Salvo F, Cannadoro G, Gonella M Int J Gen Med. 2024; 17:3201-3210.

PMID: 39070222 PMC: 11277820. DOI: 10.2147/IJGM.S470878.

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