Dynamic Coronary Blood Flow Velocity and Wall Shear Stress Estimation Using Ultrasound in an Ex Vivo Porcine Heart

Overview

Journal Cardiovasc Eng Technol

Publisher Springer

Specialties Biomedical Engineering
Cardiology & Vascular Diseases

Date 2023 Nov 14

PMID 37962814

Authors

Saeyoung Kim

Bowen Jing

Brooks A Lane

Jimena Martin Tempestti

Muralidhar Padala

Alessandro Veneziani

Brooks D Lindsey

Affiliations

Soon will be listed here.

Abstract

Purpose: Wall shear stress (WSS) is a critically important physical factor contributing to atherosclerosis. Mapping the spatial distribution of local, oscillatory WSS can identify important mechanisms underlying the progression of coronary artery disease.

Methods: In this study, blood flow velocity and time-varying WSS were estimated in the left anterior descending (LAD) coronary artery of an ex vivo beating porcine heart using ultrasound with an 18 MHz linear array transducer aligned with the LAD in a forward-viewing orientation. A pulsatile heart loop with physiologically-accurate flow was created using a pulsatile pump. The coronary artery wall motion was compensated using a local block matching technique. Next, 2D and 3D velocity magnitude and WSS maps in the LAD coronary artery were estimated at different time points in the cardiac cycle using an ultrafast Doppler approach. The blood flow velocity estimated using the presented approach was compared with a commercially-available, calibrated single element blood flow velocity measurement system.

Results: The resulting root mean square error (RMSE) of 2D velocity magnitude acquired from a high frequency, linear array transducer was less than 8% of the maximum velocity estimated by the commercial system.

Conclusion: When implemented in a forward-viewing intravascular ultrasound device, the presented approach will enable dynamic estimation of WSS, an indicator of plaque vulnerability in coronary arteries.

Citing Articles

2D array imaging system for mechanically-steered, forward-viewing ultrasound guidewire.

Olomodosi A, Strassle Rojas S, Vu P, Lindsey B Ultrasonics. 2024; 142:107398.

PMID: 39018696 PMC: 11298298. DOI: 10.1016/j.ultras.2024.107398.

References

de Korte C, Carlier S, Mastik F, Doyley M, van Der Steen A, Serruys P . Morphological and mechanical information of coronary arteries obtained with intravascular elastography; feasibility study in vivo. Eur Heart J. 2002; 23(5):405-13. DOI: 10.1053/euhj.2001.2806. View

Ge J, Erbel R, Gerber T, Gorge G, Koch L, Haude M . Intravascular ultrasound imaging of angiographically normal coronary arteries: a prospective study in vivo. Br Heart J. 1994; 71(6):572-8. PMC: 1025457. DOI: 10.1136/hrt.71.6.572. View

Agra E, Suresh K, He Q, Onohara D, Guyton R, Padala M . Left Ventricular Thinning and Distension in Pig Hearts as a Reproducible Ex Vivo Model of Functional Mitral Regurgitation. ASAIO J. 2020; 66(9):1016-1024. PMC: 7469430. DOI: 10.1097/MAT.0000000000001145. View

Riemer K, Rowland E, Leow C, Tang M, Weinberg P . Determining Haemodynamic Wall Shear Stress in the Rabbit Aorta In Vivo Using Contrast-Enhanced Ultrasound Image Velocimetry. Ann Biomed Eng. 2020; 48(6):1728-1739. PMC: 7280334. DOI: 10.1007/s10439-020-02484-2. View

Wang I, Huang H, Chang W, Huang C . Wall shear stress mapping for human femoral artery based on ultrafast ultrasound vector Doppler estimations. Med Phys. 2021; 48(11):6755-6764. DOI: 10.1002/mp.15230. View

Demene C, Deffieux T, Pernot M, Osmanski B, Biran V, Gennisson J . Spatiotemporal Clutter Filtering of Ultrafast Ultrasound Data Highly Increases Doppler and fUltrasound Sensitivity. IEEE Trans Med Imaging. 2015; 34(11):2271-85. DOI: 10.1109/TMI.2015.2428634. View

Haniel J, Yiu B, Chee A, Huebner R, Yu A . Efficacy of ultrasound vector flow imaging in tracking omnidirectional pulsatile flow. Med Phys. 2022; 50(3):1699-1714. DOI: 10.1002/mp.16168. View

Correia M, Maresca D, Goudot G, Villemain O, Bize A, Sambin L . Quantitative imaging of coronary flows using 3D ultrafast Doppler coronary angiography. Phys Med Biol. 2020; 65(10):105013. DOI: 10.1088/1361-6560/ab8d78. View

Koskinas K, Chatzizisis Y, Baker A, Edelman E, Stone P, Feldman C . The role of low endothelial shear stress in the conversion of atherosclerotic lesions from stable to unstable plaque. Curr Opin Cardiol. 2009; 24(6):580-90. PMC: 10926252. DOI: 10.1097/HCO.0b013e328331630b. View

10.

Gogas B, Yang B, Piccinelli M, Bouchi Y, King 3rd S, Dib N . Feasibility of Optical Coherence Tomography-Derived Computational Fluid Dynamics in Calcified Vessels to Assess Treatment With Orbital Atherectomy. JACC Cardiovasc Interv. 2016; 9(7):e65-6. DOI: 10.1016/j.jcin.2015.12.270. View

11.

Lindsey B, Shelton S, Martin K, Ozgun K, Rojas J, Foster F . High Resolution Ultrasound Superharmonic Perfusion Imaging: In Vivo Feasibility and Quantification of Dynamic Contrast-Enhanced Acoustic Angiography. Ann Biomed Eng. 2016; 45(4):939-948. PMC: 5682933. DOI: 10.1007/s10439-016-1753-9. View

12.

Yiu B, Yu A . Least-Squares Multi-Angle Doppler Estimators for Plane-Wave Vector Flow Imaging. IEEE Trans Ultrason Ferroelectr Freq Control. 2016; 63(11):1733-1744. DOI: 10.1109/TUFFC.2016.2582514. View

13.

Correia M, Provost J, Tanter M, Pernot M . 4D ultrafast ultrasound flow imaging: in vivo quantification of arterial volumetric flow rate in a single heartbeat. Phys Med Biol. 2016; 61(23):L48-L61. DOI: 10.1088/0031-9155/61/23/L48. View

14.

Ramalli A, Aizawa K, Shore A, Morizzo C, Palombo C, Lenge M . Continuous Simultaneous Recording of Brachial Artery Distension and Wall Shear Rate: A New Boost for Flow-Mediated Vasodilation. IEEE Trans Ultrason Ferroelectr Freq Control. 2018; 66(3):463-471. DOI: 10.1109/TUFFC.2018.2889111. View

15.

Kumar V, Liu R, Kinnick R, Gregory A, Alizad A, Belohlavek M . Unambiguous Identification and Visualization of an Acoustically Active Catheter by Ultrasound Imaging in Real Time: Theory, Algorithm, and Phantom Experiments. IEEE Trans Biomed Eng. 2017; 65(7):1468-1475. PMC: 5999572. DOI: 10.1109/TBME.2017.2749245. View

16.

Janjic J, Mastik F, Leistikow M, Bosch J, Springeling G, van der Steen A . Sparse Ultrasound Image Reconstruction From a Shape-Sensing Single-Element Forward-Looking Catheter. IEEE Trans Biomed Eng. 2018; 65(10):2210-2218. DOI: 10.1109/TBME.2017.2787060. View

17.

Salles S, Chee A, Garcia D, Yu A, Vray D, Liebgott H . 2-D arterial wall motion imaging using ultrafast ultrasound and transverse oscillations. IEEE Trans Ultrason Ferroelectr Freq Control. 2015; 62(6):1047-58. DOI: 10.1109/TUFFC.2014.006910. View

18.

Fonken J, Maas E, Nievergeld A, van Sambeek M, van de Vosse F, Lopata R . The Impact of a Limited Field-of-View on Computed Hemodynamics in Abdominal Aortic Aneurysms: Evaluating the Feasibility of Completing Ultrasound Segmentations with Parametric Geometries. Ann Biomed Eng. 2023; 51(6):1296-1309. PMC: 10172266. DOI: 10.1007/s10439-022-03133-6. View

19.

Udesen J, Arendt Jensen J . Investigation of transverse oscillation method. IEEE Trans Ultrason Ferroelectr Freq Control. 2006; 53(5):959-71. DOI: 10.1109/tuffc.2006.1632686. View

20.

Doucette J, Corl P, PAYNE H, Flynn A, Goto M, Nassi M . Validation of a Doppler guide wire for intravascular measurement of coronary artery flow velocity. Circulation. 1992; 85(5):1899-911. DOI: 10.1161/01.cir.85.5.1899. View