Pharmacological Treatment of Tourette's Syndrome: from the Past to the Future

Overview

Journal Neurol Sci

Specialty Neurology

Date 2023 Nov 14

PMID 37962703

Authors

Hao Gong

Xiangyu Du

Anping Su

Yaowu Du

Affiliations

Soon will be listed here.

Abstract

Tourette's syndrome (TS) is a neuropsychiatric disease featuring tics and vocal tics, with a prevalence of approximately 1%, including 75% of the total number of male patients. TS seriously disturbs the patients' career, education, and life and brings a serious and unbearable psychological burden to the patients themselves and their families. At present, there are no specific clinical medications recommended for treating TS. Therefore, it is necessary to select the appropriate medication for symptomatic treatment based on the doctor's personal experience and the patient's symptoms, with the main goal of relieving symptoms, thus improving the patient's social skills and psychological problems. Here we conducted a comprehensive search on PubMed to review and organize the history and current status of the development of drug therapy for TS through a timeline format. We also systematically evaluated the effects of each drug for TS treatment to summarize the current problems and new research directions and to provide some ideas for clinical treatment.

Citing Articles

Efficacy of cognitive-behavioral therapy combined with habit reversal training on anxiety disorders in children with Tourette's syndrome.

Wang Y, Zhang X, Han X World J Psychiatry. 2024; 14(7):999-1008.

PMID: 39050195 PMC: 11262930. DOI: 10.5498/wjp.v14.i7.999.

References

McNaught K, Mink J . Advances in understanding and treatment of Tourette syndrome. Nat Rev Neurol. 2011; 7(12):667-76. DOI: 10.1038/nrneurol.2011.167. View

Battle D . Diagnostic and Statistical Manual of Mental Disorders (DSM). Codas. 2014; 25(2):191-2. DOI: 10.1590/s2317-17822013000200017. View

Robertson M, Eapen V, Cavanna A . The international prevalence, epidemiology, and clinical phenomenology of Tourette syndrome: a cross-cultural perspective. J Psychosom Res. 2009; 67(6):475-83. DOI: 10.1016/j.jpsychores.2009.07.010. View

Jankovic J . Tourette's syndrome. N Engl J Med. 2001; 345(16):1184-92. DOI: 10.1056/NEJMra010032. View

Leckman J, Zhang H, Vitale A, Lahnin F, Lynch K, Bondi C . Course of tic severity in Tourette syndrome: the first two decades. Pediatrics. 1998; 102(1 Pt 1):14-9. DOI: 10.1542/peds.102.1.14. View

Jankovic J . Diagnosis and classification of tics and Tourette syndrome. Adv Neurol. 1992; 58:7-14. View

Robertson M . The Gilles de la Tourette syndrome: the current status. Arch Dis Child Educ Pract Ed. 2012; 97(5):166-75. DOI: 10.1136/archdischild-2011-300585. View

Berardelli A, Curra A, Fabbrini G, Gilio F, Manfredi M . Pathophysiology of tics and Tourette syndrome. J Neurol. 2003; 250(7):781-7. DOI: 10.1007/s00415-003-1102-4. View

Neufeld M, Berger Y, Chapman J, Korczyn A . Routine and quantitative EEG analysis in Gilles de la Tourette's syndrome. Neurology. 1990; 40(12):1837-9. DOI: 10.1212/wnl.40.12.1837. View

10.

Verma N, Lewitt P . Sensory evoked responses in Tourette syndrome. Clin Electroencephalogr. 1988; 19(2):108-10. DOI: 10.1177/155005948801900212. View

11.

Ganos C . Tics and Tourette's: update on pathophysiology and tic control. Curr Opin Neurol. 2016; 29(4):513-8. DOI: 10.1097/WCO.0000000000000356. View

12.

Hartmann A, Worbe Y . Tourette syndrome: clinical spectrum, mechanisms and personalized treatments. Curr Opin Neurol. 2018; 31(4):504-509. DOI: 10.1097/WCO.0000000000000575. View

13.

Caligiore D, Mannella F, Arbib M, Baldassarre G . Dysfunctions of the basal ganglia-cerebellar-thalamo-cortical system produce motor tics in Tourette syndrome. PLoS Comput Biol. 2017; 13(3):e1005395. PMC: 5373520. DOI: 10.1371/journal.pcbi.1005395. View

14.

Kataoka Y, Kalanithi P, Grantz H, Schwartz M, Saper C, Leckman J . Decreased number of parvalbumin and cholinergic interneurons in the striatum of individuals with Tourette syndrome. J Comp Neurol. 2009; 518(3):277-91. PMC: 2846837. DOI: 10.1002/cne.22206. View

15.

Peterson B, Thomas P, Kane M, Scahill L, Zhang H, Bronen R . Basal Ganglia volumes in patients with Gilles de la Tourette syndrome. Arch Gen Psychiatry. 2003; 60(4):415-24. DOI: 10.1001/archpsyc.60.4.415. View

16.

Singer H, Reiss A, Brown J, Aylward E, Shih B, Chee E . Volumetric MRI changes in basal ganglia of children with Tourette's syndrome. Neurology. 1993; 43(5):950-6. DOI: 10.1212/wnl.43.5.950. View

17.

Cheng B, Braass H, Ganos C, Treszl A, Biermann-Ruben K, Hummel F . Altered intrahemispheric structural connectivity in Gilles de la Tourette syndrome. Neuroimage Clin. 2013; 4:174-81. PMC: 3872720. DOI: 10.1016/j.nicl.2013.11.011. View

18.

Worbe Y, Marrakchi-Kacem L, Lecomte S, Valabregue R, Poupon F, Guevara P . Altered structural connectivity of cortico-striato-pallido-thalamic networks in Gilles de la Tourette syndrome. Brain. 2014; 138(Pt 2):472-82. PMC: 4306818. DOI: 10.1093/brain/awu311. View

19.

Yeh C, Lee C, Ma K, Lee M, Chang C, Huang W . Phasic dysfunction of dopamine transmission in Tourette's syndrome evaluated with 99mTc TRODAT-1 imaging. Psychiatry Res. 2007; 156(1):75-82. DOI: 10.1016/j.pscychresns.2007.01.003. View

20.

Hsu C, Wong L, Wang H, Lee W . The multimodality neuroimage findings in individuals with Tourette syndrome. Pediatr Neonatol. 2020; 61(5):467-474. DOI: 10.1016/j.pedneo.2020.03.007. View