Systems Genetics Approaches for Understanding Complex Traits with Relevance for Human Disease

Overview

Journal Elife

Specialty Biology

Date 2023 Nov 14

PMID 37962168

Authors

Hooman Allayee

Charles R Farber

Marcus M Seldin

Evan Graehl Williams

David E James

Aldons J Lusis

Affiliations

Soon will be listed here.

Abstract

Quantitative traits are often complex because of the contribution of many loci, with further complexity added by environmental factors. In medical research, systems genetics is a powerful approach for the study of complex traits, as it integrates intermediate phenotypes, such as RNA, protein, and metabolite levels, to understand molecular and physiological phenotypes linking discrete DNA sequence variation to complex clinical and physiological traits. The primary purpose of this review is to describe some of the resources and tools of systems genetics in humans and rodent models, so that researchers in many areas of biology and medicine can make use of the data.

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