Anaesthesia in Veterinary Oncology: The Effects of Surgery, Volatile and Intravenous Anaesthetics on the Immune System and Tumour Spread

Overview

Journal Animals (Basel)

Date 2023 Nov 14

PMID 37958147

Authors

Ana Vidal Pinheiro

Goncalo N Petrucci

Amandio Dourado

Isabel Pires

Affiliations

Soon will be listed here.

Abstract

Throughout the course of oncological disease, the majority of patients require surgical, anaesthetic and analgesic intervention. However, during the perioperative period, anaesthetic agents and techniques, surgical tissue trauma, adjuvant drugs for local pain and inflammation and other non-pharmacological factors, such as blood transfusions, hydration, temperature and nutrition, may influence the prognosis of the disease. These factors significantly impact the oncologic patient's immune response, which is the primary barrier to tumour progress, promoting a window of vulnerability for its dissemination and recurrence. More research is required to ascertain which anaesthetics and techniques have immunoprotective and anti-tumour effects, which will contribute to developing novel anaesthetic strategies in veterinary medicine.

Citing Articles

Pain Management in Animals with Oncological Disease: Opioids as Influencers of Immune and Tumor Cellular Balance.

Pinheiro A, Petrucci G, Dourado A, Silva F, Pires I Cancers (Basel). 2024; 16(17).

PMID: 39272873 PMC: 11394036. DOI: 10.3390/cancers16173015.

References

Huang Y, Yuan J, Righi E, Kamoun W, Ancukiewicz M, Nezivar J . Vascular normalizing doses of antiangiogenic treatment reprogram the immunosuppressive tumor microenvironment and enhance immunotherapy. Proc Natl Acad Sci U S A. 2012; 109(43):17561-6. PMC: 3491458. DOI: 10.1073/pnas.1215397109. View

Smith A . Advances in veterinary oncology. Vet Clin North Am Small Anim Pract. 2014; 44(5):xi-xii. DOI: 10.1016/j.cvsm.2014.06.004. View

Hume K, Johnson J, Williams L . Adverse effects of concurrent carboplatin chemotherapy and radiation therapy in dogs. J Vet Intern Med. 2009; 23(1):24-30. DOI: 10.1111/j.1939-1676.2008.0224.x. View

Braun S, Gaza N, Werdehausen R, Hermanns H, Bauer I, Durieux M . Ketamine induces apoptosis via the mitochondrial pathway in human lymphocytes and neuronal cells. Br J Anaesth. 2010; 105(3):347-54. DOI: 10.1093/bja/aeq169. View

Hashemi V, Maleki L, Esmaily M, Masjedi A, Ghalamfarsa G, Namdar A . Regulatory T cells in breast cancer as a potent anti-cancer therapeutic target. Int Immunopharmacol. 2019; 78:106087. DOI: 10.1016/j.intimp.2019.106087. View

Cummings Iii K, Zimmerman N, Maheshwari K, Cooper G, Cummings L . Epidural compared with non-epidural analgesia and cardiopulmonary complications after colectomy: A retrospective cohort study of 20,880 patients using a national quality database. J Clin Anesth. 2018; 47:12-18. PMC: 5936664. DOI: 10.1016/j.jclinane.2018.03.005. View

Lankveld D, Bull S, Van Dijk P, Fink-Gremmels J, Hellebrekers L . Ketamine inhibits LPS-induced tumour necrosis factor-alpha and interleukin-6 in an equine macrophage cell line. Vet Res. 2005; 36(2):257-62. DOI: 10.1051/vetres:2004061. View

Tyther R, Fanning N, Halligan M, Wang J, Redmond H, Shorten G . The effect of the anaesthetic agent isoflurane on the rate of neutrophil apoptosis in vitro. Ir J Med Sci. 2001; 170(1):41-4. DOI: 10.1007/BF03167720. View

Lin L, Liu C, Tan H, Ouyang H, Zhang Y, Zeng W . Anaesthetic technique may affect prognosis for ovarian serous adenocarcinoma: a retrospective analysis. Br J Anaesth. 2011; 106(6):814-22. DOI: 10.1093/bja/aer055. View

10.

Riggs J, Adams V, Hermer J, Dobson J, Murphy S, Ladlow J . Outcomes following surgical excision or surgical excision combined with adjunctive, hypofractionated radiotherapy in dogs with oral squamous cell carcinoma or fibrosarcoma. J Am Vet Med Assoc. 2018; 253(1):73-83. DOI: 10.2460/javma.253.1.73. View

11.

Wei H, Liang G, Yang H, Wang Q, Hawkins B, Madesh M . The common inhalational anesthetic isoflurane induces apoptosis via activation of inositol 1,4,5-trisphosphate receptors. Anesthesiology. 2008; 108(2):251-60. DOI: 10.1097/01.anes.0000299435.59242.0e. View

12.

Aguirre-Ghiso J . Models, mechanisms and clinical evidence for cancer dormancy. Nat Rev Cancer. 2007; 7(11):834-46. PMC: 2519109. DOI: 10.1038/nrc2256. View

13.

Gao K, Su Z, Liu H, Liu Y . Retraction notice to "Anti-proliferation and anti-metastatic effects of sevoflurane on human osteosarcoma U2OS and Saos-2 cells" [Experimental and Molecular Pathology 108 (2019) 121-130]. Exp Mol Pathol. 2022; 127:104784. DOI: 10.1016/j.yexmp.2022.104784. View

14.

Eisenhauer E, Therasse P, Bogaerts J, Schwartz L, Sargent D, Ford R . New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1). Eur J Cancer. 2008; 45(2):228-47. DOI: 10.1016/j.ejca.2008.10.026. View

15.

Brinck E, Tiippana E, Heesen M, Bell R, Straube S, Moore R . Perioperative intravenous ketamine for acute postoperative pain in adults. Cochrane Database Syst Rev. 2018; 12:CD012033. PMC: 6360925. DOI: 10.1002/14651858.CD012033.pub4. View

16.

Sheehy K, Lippold C, Rice A, Nobrega R, Finkel J, Quezado Z . Subanesthetic ketamine for pain management in hospitalized children, adolescents, and young adults: a single-center cohort study. J Pain Res. 2017; 10:787-795. PMC: 5388303. DOI: 10.2147/JPR.S131156. View

17.

Huang H, Benzonana L, Zhao H, Watts H, Perry N, Bevan C . Prostate cancer cell malignancy via modulation of HIF-1α pathway with isoflurane and propofol alone and in combination. Br J Cancer. 2014; 111(7):1338-49. PMC: 4183852. DOI: 10.1038/bjc.2014.426. View

18.

Blanco M, Moreno-Bueno G, Sarrio D, Locascio A, Cano A, Palacios J . Correlation of Snail expression with histological grade and lymph node status in breast carcinomas. Oncogene. 2002; 21(20):3241-6. DOI: 10.1038/sj.onc.1205416. View

19.

Shibata J, Ishihara S, Tada N, Kawai K, Tsuno N, Yamaguchi H . Surgical stress response after colorectal resection: a comparison of robotic, laparoscopic, and open surgery. Tech Coloproctol. 2015; 19(5):275-80. DOI: 10.1007/s10151-014-1263-4. View

20.

Yang H, Lee S, Lee S, Kim K, Yang Y, Kim J . Sox17 promotes tumor angiogenesis and destabilizes tumor vessels in mice. J Clin Invest. 2012; 123(1):418-31. PMC: 3533291. DOI: 10.1172/JCI64547. View