Mechanics of Lung Development

Overview

Journal Adv Anat Embryol Cell Biol

Specialty Anatomy & Histology

Date 2023 Nov 13

PMID 37955774

Authors

Mark Baguma-Nibasheka

Boris Kablar

Affiliations

Soon will be listed here.

Abstract

We summarize how skeletal muscle and lung developmental biology fields have been bridged to benefit from mouse genetic engineering technologies and to explore the role of fetal breathing-like movements (FBMs) in lung development, by using skeletal muscle-specific mutant mice. It has been known for a long time that FBMs are essential for the lung to develop properly. However, the cellular and molecular mechanisms transducing the mechanical forces of muscular activity into specific genetic programs that propel lung morphogenesis (development of the shape, form and size of the lung, its airways, and gas exchange surface) as well as its differentiation (acquisition of specialized cell structural and functional features from their progenitor cells) are only starting to be revealed. This chapter is a brief synopsis of the cumulative findings from that ongoing quest. An update on and the rationale for our recent International Mouse Phenotyping Consortium (IMPC) search is also provided.

Citing Articles

The impact of hormones on lung development and function: an overlooked aspect to consider from early childhood.

Pelizzo G, Calcaterra V, Baldassarre P, Marinaro M, Taranto S, Ceresola M Front Endocrinol (Lausanne). 2024; 15:1425149.

PMID: 39371928 PMC: 11449876. DOI: 10.3389/fendo.2024.1425149.

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