Expression Patterns of Claudins in Cancer

Overview

Journal Heliyon

Specialty Social Sciences

Date 2023 Nov 13

PMID 37954388

Authors

Daoyu Tao

Bingxin Guan

Hui Li

Chengjun Zhou

Affiliations

Soon will be listed here.

Abstract

Claudins are four-transmembrane proteins, which were found in tight junctions. They maintain cell barriers and regulate cell differentiation and proliferation. They are involved in maintaining cellular polarity and normal functions. Different claudins show different expression patterns. The expression level and localization of claudins are altered in various cancers. They promote or inhibit proliferation, invasion, and migration of cancer cells through multiple signaling pathways. Therefore, claudins may serve as diagnostic markers, novel therapeutic targets, and prognostic risk factors. The important roles of claudins in cancer aroused our great interest. In the present review, we provide a summary of insights into expression patterns of claudins in cancer, which is more comprehensive and provides new ideas for further research.

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