New Prospects of Cancer Therapy Based on Pyroptosis and Pyroptosis Inducers

Overview

Journal Apoptosis

Publisher Springer

Date 2023 Nov 9

PMID 37943371

Authors

Qiaoyun Chen

Yuxiang Sun

Siliang Wang

Jingyan Xu

Affiliations

Soon will be listed here.

Abstract

Pyroptosis is a gasdermin-mediated programmed cell death (PCD) pathway. It differs from apoptosis because of the secretion of inflammatory molecules. Pyroptosis is closely associated with various malignant tumors. Recent studies have demonstrated that pyroptosis can either inhibit or promote the development of malignant tumors, depending on the cell type (immune or cancer cells) and duration and severity of the process. This review summarizes the molecular mechanisms of pyroptosis, its relationship with malignancies, and focuses on current pyroptosis inducers and their significance in cancer treatment. The molecules involved in the pyroptosis signaling pathway could serve as therapeutic targets for the development of novel drugs for cancer therapy. In addition, we analyzed the potential of combining pyroptosis with conventional anticancer techniques as a promising strategy for cancer treatment.

Citing Articles

A cellular danse macabre: the choreography of programmed cell death.

Griffioen A, Nowak-Sliwinska P Apoptosis. 2025; .

PMID: 39924582 DOI: 10.1007/s10495-025-02076-2.

Research progress on the effect of pyroptosis on the occurrence, development, invasion and metastasis of colorectal cancer.

Wang X, Yin Q, Wan L, Sun R, Wang G, Gu J World J Gastrointest Oncol. 2024; 16(8):3410-3427.

PMID: 39171180 PMC: 11334039. DOI: 10.4251/wjgo.v16.i8.3410.

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