Mitochondrial Inherited Disorders and Their Correlation with Neurodegenerative Diseases

Overview

Journal Endocr Metab Immune Disord Drug Targets

Publisher Bentham Science Publishers

Specialties Allergy & Immunology
Endocrinology
Infectious Diseases
Pharmacology

Date 2023 Nov 8

PMID 37937560

Authors

Sofjana Gushi

Vasileios Balis

Affiliations

Soon will be listed here.

Abstract

Mitochondria are essential organelles for the survival of a cell because they produce energy. The cells that need more mitochondria are neurons because they perform a variety of tasks that are necessary to support brain homeostasis. The build-up of abnormal proteins in neurons, as well as their interactions with mitochondrial proteins, or MAM proteins, cause serious health issues. As a result, mitochondrial functions, such as mitophagy, are impaired, resulting in the disorders described in this review. They are also due to mtDNA mutations, which alter the heritability of diseases. The topic of disease prevention, as well as the diagnosis, requires further explanation and exploration. Finally, there are treatments that are quite promising, but more detailed research is needed.

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