Diabetes Mellitus, Energy Metabolism, and COVID-19

Overview

Journal Endocr Rev

Publisher Oxford University Press

Specialty Endocrinology

Date 2023 Nov 7

PMID 37934800

Authors

Caterina Conte

Elisa Cipponeri

Michael Roden

Affiliations

Soon will be listed here.

Abstract

Obesity, diabetes mellitus (mostly type 2), and COVID-19 show mutual interactions because they are not only risk factors for both acute and chronic COVID-19 manifestations, but also because COVID-19 alters energy metabolism. Such metabolic alterations can lead to dysglycemia and long-lasting effects. Thus, the COVID-19 pandemic has the potential for a further rise of the diabetes pandemic. This review outlines how preexisting metabolic alterations spanning from excess visceral adipose tissue to hyperglycemia and overt diabetes may exacerbate COVID-19 severity. We also summarize the different effects of SARS-CoV-2 infection on the key organs and tissues orchestrating energy metabolism, including adipose tissue, liver, skeletal muscle, and pancreas. Last, we provide an integrative view of the metabolic derangements that occur during COVID-19. Altogether, this review allows for better understanding of the metabolic derangements occurring when a fire starts from a small flame, and thereby help reducing the impact of the COVID-19 pandemic.

Citing Articles

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Alterations of hepatic lipid content following COVID-19 in persons with type 2 diabetes.

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