Small Extracellular Vesicles Administered Directly in the Brain Promote Neuroprotection and Decreased Microglia Reactivity in a Stroke Mouse Model

Herein, we investigate the bioactivity of small extracellular vesicles (sEVs), focusing on their local effect in the brain. sEVs from mononuclear cells (MNCs) showed superior effects to sEVs from mesenchymal stem cells (MSCs) and were able to promote neuroprotection and decrease microglia reactivity in a stroke mouse model.