Selective C-H Iodination of Weinreb Amides and Benzamides Through Iridium Catalysis in Solution and Under Mechanochemical Conditions

Overview

Journal Org Lett

Publisher American Chemical Society

Specialties Biochemistry
Chemistry

Date 2023 Nov 6

PMID 37931032

Authors

Amparo Sanz-Marco

Beatriz Saavedra

Elis Erbing

Jesper Malmberg

Magnus J Johansson

Belen Martin-Matute

Affiliations

Soon will be listed here.

Abstract

The acid mediated -iodination of Weinreb amides using a readily available catalyst is described. The selective -iodination of Weinreb amides, challenging substrates in directed C-H activations, and also of benzamides is achieved. The process works under mild conditions and tolerates air and moisture, having a great potential for industrial applications. The methodology can be applied under mechanochemical conditions maintaining the reaction outcome and selectivity.

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