FLOT1 Promotes Gastric Cancer Progression and Metastasis Through BCAR1/ERK Signaling

Overview

Journal Int J Biol Sci

Specialty Biology

Date 2023 Nov 6

PMID 37928269

Authors

Ran Wang

Wei Huang

Kaimei Cai

Shihan Xiao

Wuming Zhang

Xianqin Hu

Jianping Guo

Linfeng Mao

Weijie Yuan

Yi Xu

Zihua Chen

Zhikang Chen

Chen Lai

Affiliations

Soon will be listed here.

Abstract

Flotillin-1 (FLOT1) is a member of the flotillin family and serves as a hallmark of lipid rafts involved in the process of signaling transduction and vesicular trafficking. Here, we find FLOT1 promotes gastric cancer cell progression and metastasis by interacting with BCAR1, through ERK signaling. FLOT1 regulates BCAR1 phosphorylation and translocation. Overexpression of FLOT1 increases, while knockdown of FLOT1 decreases gastric cancer cell proliferation, migration and invasion. BCAR1 knockdown could block FLOT1 induced gastric cancer cell proliferation, migration and invasion. Re-expression of wildtype rather than mutant BCAR1 (Y410F) could partially restore FLOT1 knockdown induced gastric cancer cell migration and invasion, while the restore could be inhibited by ERK inhibitor. Furthermore, FLOT1 and BCAR1 expression is closely related to gastric cancer patients' poor outcome. Thus, our findings confirm that BCAR1 mediates FLOT1 induced gastric cancer progression and metastasis through ERK signaling, which may provide a novel pathway for gastric cancer treatment.

Citing Articles

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