Secreted Glycoproteins That Regulate Synaptic Function: the Dispatchers in the Central Nervous System

Overview

Journal Mol Neurobiol

Specialties Molecular Biology
Neurology

Date 2023 Nov 4

PMID 37924485

Authors

Haiying Gong

Conglei Zhu

Di Han

Sen Liu

Affiliations

Soon will be listed here.

Abstract

Glycoproteins are proteins that contain oligosaccharide chains. As widely distributed functional proteins in the body, glycoproteins are essential for cellular development, cellular function maintenance, and intercellular communication. Glycoproteins not only play a role in the cell and the membrane, but they are also secreted in the intercell. These secreted glycoproteins are critical to the central nervous system for neurodevelopment and synaptic transmission. More specifically, secreted glycoproteins play indispensable roles in neurite growth mediation, axon guiding, synaptogenesis, neuronal differentiation, the release of synaptic vesicles, subunit composition of neurotransmitter receptors, and neurotransmitter receptor trafficking among other things. Abnormal expressions of secreted glycoproteins in the central nervous system are associated with abnormal neuron development, impaired synaptic organization/transmission, and neuropsychiatric disorders. This article reviews the secreted glycoproteins that regulate neuronal development and synaptic function in the central nervous system, and the molecular mechanism of these regulations, providing reference for research about synaptic function regulation and related central nervous system diseases.

Citing Articles

Unique Glycans in Synaptic Glycoproteins in Mouse Brain.

Noel M, Suttapitugsakul S, Wei M, Tilton C, Mehta A, Matsumoto Y ACS Chem Neurosci. 2024; 15(21):4033-4045.

PMID: 39401784 PMC: 11587512. DOI: 10.1021/acschemneuro.4c00399.

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