Toward the Understanding of DSG2 and CD46 Interaction with HAdV-11 Fiber, a Super-complex Analysis

Overview

Journal J Virol

Publisher American Society for Microbiology

Date 2023 Nov 3

PMID 37921471

Authors

Gregory Effantin

Marc-Andre Hograindleur

Daphna Fenel

Pascal Fender

Emilie Vassal-Stermann

Affiliations

Soon will be listed here.

Abstract

The main limitation of oncolytic vectors is neutralization by blood components, which prevents intratumoral administration to patients. Enadenotucirev, a chimeric HAdV-11p/HAdV-3 adenovirus identified by bio-selection, is a low seroprevalence vector active against a broad range of human carcinoma cell lines. At this stage, there's still some uncertainty about tropism and primary receptor utilization by HAdV-11. However, this information is very important, as it has a direct influence on the effectiveness of HAdV-11-based vectors. The aim of this work is to determine which of the two receptors, DSG2 and CD46, is involved in the attachment of the virus to the host, and what role they play in the early stages of infection.

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