The Homing of Exogenous Hair Follicle Mesenchymal Stem Cells into Hair Follicle Niches

Overview

Journal JCI Insight

Specialties Biomedical Engineering
General Medicine

Date 2023 Nov 2

PMID 37917167

Authors

Kaitao Li

Fang Liu

Ye He

Qian Qu

Pingping Sun

Lijuan Du

Jin Wang

Ruosi Chen

Yuyang Gan

Danlan Fu

Zhexiang Fan

Bingcheng Liu

Zhiqi Hu

Yong Miao

Affiliations

Soon will be listed here.

Abstract

Hair loss is a debilitating condition associated with the depletion of dermal papilla cells (DPCs), which can be replenished by dermal sheath cells (DSCs). Hence, strategies aimed at increasing the populations of DPCs and DSCs hold promise for the treatment of hair loss. In this study, we demonstrated in mice that introduced exogenous DPCs and DSCs (hair follicle mesenchymal stem cells) could effectively migrate and integrate into the dermal papilla and dermal sheath niches, leading to enhanced hair growth and prolonged anagen phases. However, the homing rates of DPCs and DSCs were influenced by various factors, including recipient mouse depilation, cell passage number, cell dose, and immune rejection. Through in vitro and in vivo experiments, we also discovered that the CXCL13/CXCR5 pathway mediated the homing of DPCs and DSCs into hair follicle niches. This study underscores the potential of cell-based therapies for hair loss by targeted delivery of DPCs and DSCs to their respective niches and sheds light on the intriguing concept that isolated mesenchymal stem cells can home back to their original niche microenvironment.

Citing Articles

Reprofiling synthetic glucocorticoid-induced leucine zipper fusion peptide as a novel and effective hair growth promoter.

Naeini S, Bhandari B, Gouron J, Rogers H, Chagas P, Naeini G Arch Dermatol Res. 2024; 316(5):190.

PMID: 38775976 DOI: 10.1007/s00403-024-02988-0.

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