Divergent Mechanisms of Inflammasome Activation in Neutrophil Early Response and Inflammation

Overview

Journal Nat Immunol

Date 2023 Nov 2

PMID 37914819

Authors

Sergio D Catz

Affiliations

Soon will be listed here.

References

Ley K, Hoffman H, Kubes P, Cassatella M, Zychlinsky A, Hedrick C . Neutrophils: New insights and open questions. Sci Immunol. 2018; 3(30). DOI: 10.1126/sciimmunol.aat4579. View

Zarbock A, Ley K . Neutrophil adhesion and activation under flow. Microcirculation. 2008; 16(1):31-42. PMC: 2851240. DOI: 10.1080/10739680802350104. View

Hidalgo A, Peired A, Wild M, Vestweber D, Frenette P . Complete identification of E-selectin ligands on neutrophils reveals distinct functions of PSGL-1, ESL-1, and CD44. Immunity. 2007; 26(4):477-489. PMC: 4080624. DOI: 10.1016/j.immuni.2007.03.011. View

Pruenster M, Immler R, Roth J, Kuchler T, Bromberger T, Napoli M . E-selectin-mediated rapid NLRP3 inflammasome activation regulates S100A8/S100A9 release from neutrophils via transient gasdermin D pore formation. Nat Immunol. 2023; 24(12):2021-2031. PMC: 10681899. DOI: 10.1038/s41590-023-01656-1. View

Pruenster M, Kurz A, Chung K, Cao-Ehlker X, Bieber S, Nussbaum C . Extracellular MRP8/14 is a regulator of β2 integrin-dependent neutrophil slow rolling and adhesion. Nat Commun. 2015; 6:6915. PMC: 4411303. DOI: 10.1038/ncomms7915. View

Brydges S, Broderick L, McGeough M, Pena C, Mueller J, Hoffman H . Divergence of IL-1, IL-18, and cell death in NLRP3 inflammasomopathies. J Clin Invest. 2013; 123(11):4695-705. PMC: 3809806. DOI: 10.1172/JCI71543. View

Strowig T, Henao-Mejia J, Elinav E, Flavell R . Inflammasomes in health and disease. Nature. 2012; 481(7381):278-86. DOI: 10.1038/nature10759. View

Karmakar M, Minns M, Greenberg E, Diaz-Aponte J, Pestonjamasp K, Johnson J . N-GSDMD trafficking to neutrophil organelles facilitates IL-1β release independently of plasma membrane pores and pyroptosis. Nat Commun. 2020; 11(1):2212. PMC: 7200749. DOI: 10.1038/s41467-020-16043-9. View

Jorch S, McNally A, Berger P, Wolf J, Kaiser K, Chetrusca Covash A . Complex regulation of alarmins S100A8/A9 and secretion via gasdermin D pores exacerbates autoinflammation in familial Mediterranean fever. J Allergy Clin Immunol. 2023; 152(1):230-243. DOI: 10.1016/j.jaci.2023.01.037. View

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Johnson J, Ramadass M, Haimovich A, McGeough M, Zhang J, Hoffman H . Increased Neutrophil Secretion Induced by Mutation Links the Inflammasome to Azurophilic Granule Exocytosis. Front Cell Infect Microbiol. 2018; 7:507. PMC: 5732154. DOI: 10.3389/fcimb.2017.00507. View