Kinins Induce Rapid Structural Changes in Colon Concomitant with Chloride Secretion

Overview

Journal Cell Tissue Res

Specialties Anatomy & Histology
Cell Biology

Date 1986 Jan 1

PMID 3791384

Citations 2

Authors

D A Baron

D H Miller

H S Margolius

Affiliations

Soon will be listed here.

Abstract

Voltage-clamped colonic epithelia were fixed for morphological observation minutes after bradykinin was added to produce its well-characterized increase in short circuit current representing net chloride secretion. With respect to paired controls, the average distance from the luminal epithelial surface to the underlying muscularis mucosa decreased significantly with time, and was accompanied by marked structural alterations in the crypts of Lieberkühn and surrounding lamina propria. This rapid reconfiguration of epithelial architecture suggests that kinin-receptor interaction leads to epithelial contractile events which occur simultaneously with net chloride secretion.

Citing Articles

Bradykinin modulates mucin secretion but not synthesis from an intestinal goblet cell line.

Stanley C, Phillips T Agents Actions. 1994; 42(3-4):141-5.

PMID: 7879699 DOI: 10.1007/BF01983480.

Molecular biology of tissue kallikrein.

MacDonald R, Margolius H, Erdos E Biochem J. 1988; 253(2):313-21.

PMID: 3052422 PMC: 1149300. DOI: 10.1042/bj2530313.

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