Pathogenesis of Heart Block in a Fatal Case of Dermatomyositis

Overview

Journal Br Heart J

Specialty Cardiology & Vascular Diseases

Date 1986 Nov 1

PMID 3790384

Citations 5

Authors

W M Behan

M Aitchison

P O Behan

Affiliations

Soon will be listed here.

Abstract

Approximately 70% of patients with dermatomyositis have evidence of cardiac damage; in one third of cases this affects principally or solely the conduction tissue. In infants similar histological lesions have been associated with a maternal autoantibody, anti-Ro, that crosses the placenta and produces congenital heart block. Anti-Ro antibody was detected in a fatal case of dermatomyositis with lesions of the conduction system.

Citing Articles

Should Physicians Be Aware of Rhythm Disturbances in Adults with Systemic Autoimmune Diseases and Anti-Ro52 Antibodies? A Cross-Sectional Study.

Gamazo-Herrero J, Medina-Luezas J, Cusacovich I, Martin-Asenjo M, Gonzalez-Montagut-Gomez C, Sanchez-Gonzalez M J Clin Med. 2024; 13(12).

PMID: 38930039 PMC: 11204400. DOI: 10.3390/jcm13123510.

Cardiac involvement in adult and juvenile idiopathic inflammatory myopathies.

Schwartz T, Diederichsen L, Lundberg I, Sjaastad I, Sanner H RMD Open. 2016; 2(2):e000291.

PMID: 27752355 PMC: 5051430. DOI: 10.1136/rmdopen-2016-000291.

Juvenile dermatomyositis with a rare and remarkable complication: sinus bradycardia.

Karaca N, Aksu G, Yeniay B, Kutukculer N Rheumatol Int. 2006; 27(2):179-82.

PMID: 16944159 DOI: 10.1007/s00296-006-0191-7.

Cardiac damage in polymyositis associated with antibodies to tissue ribonucleoproteins.

Behan W, Behan P, Gairns J Br Heart J. 1987; 57(2):176-80.

PMID: 3493020 PMC: 1277101. DOI: 10.1136/hrt.57.2.176.

Humoral immune response to cardiac conducting tissue.

Lotze U, Maisch B Springer Semin Immunopathol. 1989; 11(4):409-22.

PMID: 2694408 DOI: 10.1007/BF00201879.

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