Population-specific Mutation Patterns in Breast Tumors from African American, European American, and Kenyan Patients

Overview

Journal Cancer Res Commun

Specialty Oncology

Date 2023 Oct 30

PMID 37902422

Authors

Wei Tang

Flora Zhang

Jung S Byun

Tiffany H Dorsey

Harris G Yfantis

Anuoluwapo Ajao

Huaitian Liu

Margaret S Pichardo

Catherine M Pichardo

Alexandra R Harris

Xiaohong R Yang

Jonine D Figueroa

Shahin Sayed

Francis W Makokha

Stefan Ambs

Affiliations

Soon will be listed here.

Abstract

Significance: The study describes differences in tumor mutational profiles between African American, European American, and Kenyan breast cancer patients. It also investigates how these profiles may relate to the tumor immune environment and the neighborhood environment in which the patients had residence. Finally, it describes an overrepresentation of ARID1A gene mutations in breast tumors of the Kenyan patients.

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