The Influence of Poly(ethylene Glycol) 6000 on Spermine-induced Aggregation of Liposomes

Overview

Journal Biochem J

Specialty Biochemistry

Date 1986 Jun 15

PMID 3790085

Citations 2

Authors

B Tadolini

E Varani

L Cabrini

Affiliations

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Abstract

Poly(ethylene glycol) 6000 affected the aggregation of mixed liposomes induced by spermine. It lowered the concentration of spermine causing 50% maximal aggregation, accelerated the rate and increased the extent of aggregation. The effect was inversely proportional to the density of the acidic phospholipid in the vesicles. These effects were not due either to poly(ethylene glycol) 6000-induced permanent structural modification of the liposome or increased binding of spermine to the vesicles. These findings are discussed in relation to a decreased hydration force caused by the ability of poly(ethylene glycol) 6000 to alter the water of hydration of the phospholipid polar groups in the liposome.

Citing Articles

Inhibitory action of polyamines on protein kinase C association to membranes.

Moruzzi M, Barbiroli B, Monti M, Tadolini B, Hakim G, Mezzetti G Biochem J. 1987; 247(1):175-80.

PMID: 3479981 PMC: 1148385. DOI: 10.1042/bj2470175.

Influence of polyamines on membrane functions.

Schuber F Biochem J. 1989; 260(1):1-10.

PMID: 2673211 PMC: 1138618. DOI: 10.1042/bj2600001.

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