HOXC Cluster Antisense RNA 3, a Novel Long Non-Coding RNA As an Oncological Biomarker and Therapeutic Target in Human Malignancies

Overview

Journal Onco Targets Ther

Publisher Dove Medical Press

Specialty Oncology

Date 2023 Oct 30

PMID 37899986

Authors

Yunhe Xie

Jiarong Ye

Hongliang Luo

Affiliations

Soon will be listed here.

Abstract

HOXC cluster antisense RNA 3 (HOXC-AS3) is a novel long noncoding RNA (lncRNA) that exhibits aberrant expression patterns in various cancer types. Its expression is closely related to clinicopathological features, demonstrating significant clinical relevance across multiple tumors. And HOXC-AS3 plays multifaceted roles in tumor progression, impacting cell proliferation, apoptosis, migration, invasion, epithelial-mesenchymal transition (EMT), autophagy, senescence, tumor growth, and metastasis. In this review, we summarized and comprehensively analyzed the expression and clinical significance of HOXC-AS3 as a diagnostic and prognostic biomarker for malignancies. Additionally, we presented an in-depth update on HOXC-AS3's functions and regulatory mechanisms in cancer pathogenesis. This narrative review underscores the importance of HOXC-AS3 as a promising lncRNA candidate in cancer research and its potential as a predictive biomarker and therapeutic target in clinical applications.

Citing Articles

Long Noncoding RNA VLDLR-AS1 Levels in Serum Correlate with Combat-Related Chronic Mild Traumatic Brain Injury and Depression Symptoms in US Veterans.

Patel R, Krause-Hauch M, Kenney K, Miles S, Nakase-Richardson R, Patel N Int J Mol Sci. 2024; 25(3).

PMID: 38338752 PMC: 10855201. DOI: 10.3390/ijms25031473.

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