Modulatory Properties of Methanolic Extracts on Targeted Genes in Colorectal Cancer Management

Overview

Journal Cancers (Basel)

Publisher MDPI

Specialty Oncology

Date 2023 Oct 28

PMID 37894369

Authors

John M Macharia

Timea Varjas

Ruth W Mwangi

Zsolt Kaposztas

Nora Rozmann

Marton Pinter

Isabel N Wagara

Bence L Raposa

Affiliations

Soon will be listed here.

Abstract

Colon tumors have a very complicated and poorly understood pathogenesis. Plant-based organic compounds might provide a novel source for cancer treatment with a sufficient novel mode of action. The objective of this study was to analyze and evaluate the efficacy of (AS) methanolic extracts on the expression of , , , , and in colorectal cancer (CRC) management. Caco-2 cell lines were used in the experimental study. In the serial exhaustive extraction (SEE) method, methanol was utilized as the extraction solvent. Upon treatment of with the methanolic extracts, the expression of the genes was progressively upregulated, thus, dose-dependently increasing the rate of apoptosis. On the other hand, the expressions of , , and were variably downregulated in a dose-dependent manner. This is a unique novel study that evaluated the effects of AS methanolic extracts in vitro on CRC cell lines using different dosage concentrations. We, therefore, recommend the utilization of AS and the application of methanol as the extraction solvent of choice for maximum modulatory benefits in CRC management. In addition, we suggest research on the specific metabolites in AS involved in the modulatory pathways that suppress the development of CRC and potential metastases.

Citing Articles

In Vitro Inhibition of Colorectal Cancer Gene Targets by L. Methanolic Extracts: A Focus on Specific Genome Regulation.

Macharia J, Pande D, Zand A, Budan F, Kaposztas Z, Kovesdi O Nutrients. 2024; 16(8).

PMID: 38674831 PMC: 11054881. DOI: 10.3390/nu16081140.

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