Clinical Characteristics, Antimicrobial Resistance, Virulence Genes and Multi-Locus Sequence Typing of Non-Typhoidal Serovar Typhimurium and Enteritidis Strains Isolated from Patients in Chiang Mai, Thailand

Overview

Journal Microorganisms

Specialty Microbiology

Date 2023 Oct 28

PMID 37894083

Authors

Songphon Buddhasiri

Chutikarn Sukjoi

Arishabhas Tantibhadrasapa

Panupon Mongkolkarvin

Pattarapon Boonpan

Thanakorn Pattanadecha

Nattamon Onton

Touch Laisiriroengrai

Sunatcha Coratat

Banyong Khantawa

Surapun Tepaamorndech

Kwanjit Duangsonk

Parameth Thiennimitr

Affiliations

Soon will be listed here.

Abstract

Non-typhoidal (NTS) caused by ingesting contaminated food or drink remains a major bacterial foodborne disease. Clinical outcomes of NTS range from self-limited gastroenteritis to life-threatening invasive NTS (iNTS). In this study, we isolated spp. from the stool and blood of patients hospitalized at Maharaj Nakorn Chiang Mai Hospital, Chiang Mai, Thailand, between 2016-2021 (a total of 395 cases). Then, serovar Typhimurium and Enteritidis were identified and further characterized by multiplex PCR, and multi-locus sequence typing. Our data show that multidrug resistance (MDR) sequence type 34 (ST34) and ST11 are the predominant sequence types for serovars Typhimurium and Enteritidis, respectively. Most ST34 lacks , and most ST11 harbor , , and genes. NTS can be found in a wide range of ages, and anemia could be a significant factor for infection (86.3%). Both (6.7%) and (25.0%) can cause iNTS in immunocompromised patients. conferred MDR phenotype higher than with multiple antibiotic resistance indexes of 0.22 and 0.04, respectively. Here, we characterized the important , , and human clinical factors of NTS within the region.

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