Identification of the Gene in the First Mucoid XDR Isolated from a Patient with Cystic Fibrosis

Overview

Journal J Clin Med

Specialty General Medicine

Date 2023 Oct 28

PMID 37892720

Authors

Martina Rossitto

Gianluca Vrenna

Vanessa Tuccio Guarna Assanti

Nour Essa

Maria Luisa De Santis

Annarita Granaglia

Vanessa Fini

Valentino Costabile

Manuela Onori

Luca Cristiani

Alessandra Boni

Renato Cutrera

Carlo Federico Perno

Paola Bernaschi

Affiliations

Soon will be listed here.

Abstract

is one of the pathogens most involved in health care-associated infections in recent decades. Known for its ability to accumulate several antimicrobial resistance mechanisms, it possesses the oxacillinase , a carbapenemase now endemic in Italy. species are not frequently observed in patients with cystic fibrosis, and multidrug-resistant is a rare event in these patients. Non-mucoid carrying the gene has been sporadically detected. Here, we describe the methods used to detect in the first established case of pulmonary infection via a mucoid strain of producing carbapenemase in a 24-year-old cystic fibrosis patient admitted to Bambino Gesù Children's Hospital in Rome, Italy. This strain, which exhibited an extensively drug-resistant antibiotype, also showed a great ability to further increase its resistance in a short time.

Citing Articles

Decoding the resistome, virulome and mobilome of clinical aquatic in southern Romania.

Gheorghe-Barbu I, Surleac M, Czobor Barbu I, Paraschiv S, Banica L, Rotaru L Heliyon. 2024; 10(13):e33372.

PMID: 39035534 PMC: 11259834. DOI: 10.1016/j.heliyon.2024.e33372.

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