Characteristics of Metabolites in the Development of Atherosclerosis in Tibetan Minipigs Determined Using Untargeted Metabolomics

Overview

Journal Nutrients

Date 2023 Oct 28

PMID 37892500

Authors

Liye Shen

Jinlong Wang

Yongming Pan

Junjie Huang

Keyan Zhu

Haiye Tu

Minli Chen

Affiliations

Soon will be listed here.

Abstract

Background: Atherosclerosis (AS) is a chronic progressive disease caused by lipometabolic disorder. However, the pathological characteristics and mechanism of AS have not been fully clarified. Through high-fat and high-cholesterol diet induction, Tibetan minipigs can be used as the AS model animals, as they have a very similar AS pathogenesis to humans.

Methods: In this study, we built an AS model of Tibetan minipigs and identified the differential abundance metabolites in the development of AS based on untargeted metabolomics.

Results: We found that sphingolipid metabolism and glucose oxidation were obviously higher in the AS group and phenylalanine metabolism was reduced in the AS group. Moreover, in the development of AS, gluconolactone was enriched in the late stage of AS whereas biopterin was enriched in the early stage of AS.

Conclusions: Our research provides novel clues to investigate the metabolic mechanism of AS from the perspective of metabolomics.

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