Does the Protective Effect of Zinc on Telomere Length Depend on the Presence of Hypertension or Type 2 Diabetes? Results from the Iwaki Health Promotion Project, Japan

Overview

Journal Nutrients

Date 2023 Oct 28

PMID 37892448

Authors

Mahiro Sato

Kyi Mar Wai

Ken Itoh

Yichi Yang

Yuka Uchikawa

Yukihiko Ito

Shigeyuki Nakaji

Kazushige Ihara

Affiliations

Soon will be listed here.

Abstract

Telomeres, repeated TTAGGG sequences at chromosomal ends, shorten with age and indicate cellular lifespan. Zinc can protect against telomere damage through its anti-oxidative effect. Meanwhile, telomere shortening was correlated with metabolic diseases of hypertension and type 2 diabetes. The objective of this study was to investigate whether the association between zinc and telomere length differs by the presence or absence of hypertension/type 2 diabetes. This is a cross-sectional study with 1064 participants of the Iwaki area, Japan. Multiple linear regression models were performed to test the hypothesis. A higher serum zinc concentration was significantly associated with a longer G-tail length (β = 48.11, 95% confidence intervals [CI]: 25.69, 70.54, < 0.001). By multivariate linear regression analysis, there was a significant positive association between zinc and G-tail length in both hypertensive (β = 46.84, 95%CI: 9.69, 84.0, = 0.014) and non-hypertensive groups (β = 49.47, 95%CI: 20.75, 78.18, = 0.001), while the association was significant only in the non-diabetes group (β = 50.82, 95%CI: 27.54, 74.11, < 0.001). In conclusion, higher zinc concentration was significantly associated with longer G-tail length. The protective effect of zinc on G-tail did not differ by hypertension status; however, it disappeared in individuals with type 2 diabetes.

Citing Articles

Dietary Zinc Intake and the Association of Insulin Level and HOMA-IR with Telomere Shortening in Mexican Children.

Vazquez-Moreno M, Perales-Herrera A, Ramirez-Silva I, Martinez-Gomez L, Garcia-Ceron A, Paredes-Barrientos J Biol Trace Elem Res. 2024; .

PMID: 39110381 DOI: 10.1007/s12011-024-04329-8.

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