Nasal Nitric Oxide in Children: A Review of Current Outreach in Pediatric Respiratory Medicine

Overview

Journal Children (Basel)

Specialty Health Services

Date 2023 Oct 28

PMID 37892334

Authors

Iva Mrkic Kobal

Mirjana Turkalj

Davor Plavec

Affiliations

Soon will be listed here.

Abstract

Nasal nitric oxide (nNO) is a gas synthesized by the inducible and constitutive NO synthase (NOS) enzyme in the airway cells of the nasal mucosa. Like lung nitric oxide, it is thought to be associated with airway inflammation in various respiratory diseases in children. The aim of our review was to investigate the current state of use of nNO measurement in children. A comprehensive search was conducted using the Web of Science and PubMed databases specifically targeting publications in the English language, with the following keywords: nasal NO, children, allergic rhinitis, chronic rhinosinusitis, acute rhinosinusitis, primary ciliary dyskinesia (PCD), and cystic fibrosis (CF). We describe the use of nNO in pediatric allergic rhinitis, chronic rhinosinusitis, acute rhinosinusitis, PCD, and CF based on the latest literature. nNO is a noninvasive, clinically applicable test for use in pediatric allergic rhinitis, chronic rhinosinusitis, acute rhinosinusitis, PCD, and CF. It can be used as a complementary method in the diagnosis of these respiratory diseases and as a monitoring method for the treatment of allergic rhinitis and acute and chronic rhinosinusitis.

Citing Articles

V Brazilian Consensus on Rhinitis - 2024.

Sole D, Kuschnir F, Pastorino A, Constantino C, Galvao C, Chong E Silva D Braz J Otorhinolaryngol. 2024; 91(1):101500.

PMID: 39388827 PMC: 11497470. DOI: 10.1016/j.bjorl.2024.101500.

Current Challenges in Pediatric Asthma.

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