Supersaturable Solid Self-microemulsifying Delivery Systems of Astaxanthin Via Spray Drying: Effects of Polymers and Solid Carriers

Overview

Journal AAPS PharmSciTech

Publisher Springer

Specialty Pharmacology

Date 2023 Oct 27

PMID 37891405

Authors

Wai Thet Aung

Peerawas Kopongpanich

Veerakiet Boonkanokwong

Affiliations

Soon will be listed here.

Abstract

This study aimed to develop the solid astaxanthin-encapsulated self-microemulsifying delivery system (S-AST SMEDS) spray-dried particles and investigate the effect of materials in formulations on product characteristics. The optimized liquid AST SMEDS incorporated with a polymeric precipitation inhibitor (PI) was solidified with a solid carrier by spray drying. Physicochemical properties of S-AST SMEDS spray-dried powders including morphology, particle size and distribution, flowability, solid-state characters, moisture content, yield, loading capacity of AST, and reconstitution properties were examined. Polymeric PIs seemed to have an impact on particles' size, surface smoothness, and flowability while solid carriers had an effect on the particles' moisture content and droplet size of microemulsions obtained after reconstitution. The amount of AST encapsulated in S-SMEDS powder was influenced by both polymer and solid carriers. Dissolution and short-term stability of S-AST SMEDS were also studied. Our developed spray-dried solid SMEDS particles helped enhance AST dissolution rate.

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