Host Susceptibility to Nontuberculous Mycobacterial Pulmonary Disease

Overview

Journal Clin Chest Med

Specialty Pulmonary Medicine

Date 2023 Oct 27

PMID 37890911

Authors

Ho Namkoong

Steven M Holland

Affiliations

Soon will be listed here.

Abstract

Nontuberculous mycobacteria (NTM) pulmonary disease is a chronic progressive pulmonary infectious disease caused by low virulence pathogens. The existence of host susceptibility to NTM infection has been recognized from a high incidence among Asians compared to other populations in the United States, a high incidence among slender, middle-aged women, and the presence of familial clusters. Recent whole exome sequencing and genome-wide association studies have identified immune, CFTR, cilia, connective tissue and ion homeostasis genes as host susceptibility genes. Large-scale international collaborative studies and functional analyses are expected to elucidate host susceptibility in the future.

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