Epithelial Membrane Protein-3 and Chitinase-3-like Protein-1 As New Prognostic Predictors of Glioma, a Two-Gene Study

Overview

Journal Curr Oncol

Publisher MDPI

Specialty Oncology

Date 2023 Oct 27

PMID 37887529

Authors

Kecheng Shen

Jiandong Zhu

Shijie Zhou

Xin Jin

Weiwei Zhai

Liang Sun

Jiang Wu

Zhengquan Yu

Affiliations

Soon will be listed here.

Abstract

Background: Glioblastoma multiforme is the most common primary intracranial tumor, with a high degree of malignancy, poor therapeutic effect, and poor prognosis. According to previous studies, CHI3L1 and EMP3 are two independent tumor predictors that are of great significance for the prognostic prediction of other tumors, and their expression levels may be related to the prognosis of glioma patients.

Methods: using Oncomine, Gene Expression Profiling Interactive Analysis (GEPIA), the Chinese Glioma Genome Atlas (CGGA), cBioPortal, LinkedOmics, and other databases, 693 glioma patients were screened to analyze the relationship between EMP3 and CHI3L1 expression and prognosis in glioma patients.

Results: low-grade glioma patients with a low expression of EMP3/CHI3L1 had a better prognosis, and the combination of EMP3/CHI3L1 is a new predictor for glioma patients.

Conclusion: We used the TCGA and CGGA databases to analyze the effect of EMP3 and CHI3L1 expression on the prognosis of glioma patients and their correlation with gene expression using bioinformation analysis. The results showed that low-grade glioma patients with a low expression of EMP3 and CHI3L1 had a better prognosis, and EMP3 and CHI3L1 co-expression genes were correlated. The combination of these two factors could be a new prognostic index for glioma patients.

Citing Articles

Liu Z, Fan H, Liu X, Liu C Discov Oncol. 2024; 15(1):296.

PMID: 39033204 PMC: 11264614. DOI: 10.1007/s12672-024-01126-6.

Tang W, Du J, Li L, Hu S, Ma S, Xue M J Cell Mol Med. 2024; 28(10):e18393.

PMID: 38809929 PMC: 11135907. DOI: 10.1111/jcmm.18393.

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