Systematic Review and Meta-analysis of the Efficacy of Exercise Intervention in Kidney Transplant Recipients

Overview

Journal World J Urol

Specialty Urology

Date 2023 Oct 26

PMID 37882807

Authors

Dongxu Zhang

Liqian Yu

Bowen Xia

Xin Zhang

Pu Liang

Xiaopeng Hu

Affiliations

Soon will be listed here.

Abstract

Background And Objective: There is uncertainty about the beneficial effects of exercise intervention for kidney transplant recipients. The purpose of our meta-analysis is to estimate the efficacy of exercise intervention in kidney transplant recipients.

Methods: A database search according to the PICOS framework was performed for all published randomized, double-blind, placebo-controlled trials (RCTs) about exercise intervention for kidney transplant recipients. The databases involved include PubMed, Embase, and Cochrane Library.

Results: A total of 16 RCTs (involving 827 patients) in compliance with inclusion criteria were included in our study. The results demonstrated that adequate exercise intervention improved statistically in creatinine clearance [mean difference (MD) = - 0.29, 95% confidence interval (CI) - 0.46 to - 0.11, p = 0.001], serum urea (MD = - 21.57, 95% CI - 35.84 to - 7.29, p = 0.003), VO peak (MD = 3.20, 95% CI 1.97-4.43, p < 0.00001), high-density lipoprotein-cholesterol (HDL-C) (MD = 0.21, 95% CI 0.04-0.37, p = 0.01), 60-s sit to stand test (60-STS) (MD = 14.47, 95% CI 8.89-20.04, p < 0.00001), 6-min walk distance (6-MWD) (MD = 91.87, 95% CI 38.34-145.39, p = 0.0008), and 6-min walk test (6-MWT) (MD = 44.08, 95% CI 20.30-67.87, p = 0.0003) of patients after kidney transplantation. No between-groups differences (p > 0.05) were observed for anthropometric characteristics, body composition, serum cytokine levels, and quality of life short form-36 questionnaire (SF-36).

Conclusions: In kidney transplant recipients, appropriate exercise intervention improved renal function, cardiopulmonary function, physical performance.

Trial Registration: The PROSPERO registration number is CRD42022357574.

Citing Articles

Supervised home-based exercise program in kidney transplant recipients: A pilot pragmatic non-randomized study.

Crepaldi A, Piva G, Lamberti N, Felisatti M, Pomidori L, Battaglia Y World J Transplant. 2024; 14(4):96244.

PMID: 39697462 PMC: 11438937. DOI: 10.5500/wjt.v14.i4.96244.

Tailored exercise with telehealth monitoring improves adherence and global health in kidney transplant recipients.

Vecchiato M, Duregon F, Zanardo E, Baioccato V, Quinto G, Livio A Front Sports Act Living. 2024; 6:1436742.

PMID: 39346494 PMC: 11438482. DOI: 10.3389/fspor.2024.1436742.

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