» Articles » PMID: 37877108

Kikuchi-Fujimoto Disease: A Case of Febrile Cervical Lymphadenopathy With Hematological Abnormalities

Overview
Journal Cureus
Date 2023 Oct 25
PMID 37877108
Authors
Affiliations
Soon will be listed here.
Abstract

Kikuchi-Fujimoto disease (KFD), or histiocytic necrotizing lymphadenitis, is a benign but rare disorder associated with febrile cervical lymphadenopathy in young adults. Here, we discuss a case of a young female patient presenting with left tender cervical lymphadenopathy that progressed bilaterally with a fever of unknown origin. Laboratory parameters showed persistent leukopenia, especially neutropenia, which fluctuated with the degree of symptom severity. Two months were taken to confirm the diagnosis of KFD based on the histological interpretation of the lymph node biopsy. Supportive management with analgesics and paracetamol formed the main treatment. This case highlights the challenges and importance of diagnosing KFD to exclude other serious conditions such as lymphoma, tuberculosis, or lupus lymphadenitis that share similar clinical manifestations as KFD.

References
1.
Song J, Cheong H, Kee S, Lee J, Sohn J, Kim M . Disease spectrum of cervical lymphadenitis: analysis based on ultrasound-guided core-needle gun biopsy. J Infect. 2007; 55(4):310-6. DOI: 10.1016/j.jinf.2007.06.004. View

2.
Pandit S, Das A, Choudhury S, Das S . A rare case of Kikuchi-Fujimoto disease. J Nat Sci Biol Med. 2013; 4(2):490-2. PMC: 3783810. DOI: 10.4103/0976-9668.116996. View

3.
Fidai S, Cipriani N, Ginat D . Histiocytic Necrotizing Lymphadenitis Involving the Neck: Radiology-Pathology Correlation. Head Neck Pathol. 2018; 13(4):648-651. PMC: 6854164. DOI: 10.1007/s12105-018-0936-0. View

4.
Kucukardali Y, Solmazgul E, Kunter E, Oncul O, Yildirim S, Kaplan M . Kikuchi-Fujimoto Disease: analysis of 244 cases. Clin Rheumatol. 2006; 26(1):50-4. DOI: 10.1007/s10067-006-0230-5. View

5.
Yu S, Chen C, Huang H, Chen T, Wang C, Lou P . Diagnosis of Kikuchi-Fujimoto disease: a comparison between open biopsy and minimally invasive ultrasound-guided core biopsy. PLoS One. 2014; 9(5):e95886. PMC: 4008434. DOI: 10.1371/journal.pone.0095886. View