Topical Administration of S. Salivarius 24SMB-S. Oralis 89a in Children with Adenoidal Disease: a Double-blind Controlled Trial

Overview

Journal Eur J Pediatr

Specialty Pediatrics

Date 2023 Oct 24

PMID 37874401

Authors

Francesco Folino

Daniele Di Pasquale

Paola Marchisio

Lorenzo Pignataro

Pasquale Capaccio

Lorenzo Gaini

Ludovica Battilocchi

Samantha Bosis

Sara Torretta

Affiliations

Soon will be listed here.

Abstract

Conclusions: Our findings document a positive effect of Rinogermina spray in achieving reduction in the blockage of nasopharynx space by hypertrophic adenoids, thus suggesting that its use into the integrated therapeutic management of children with CA could be of a certain utility.

What Is Known: • Chronic adenoiditis in children results from an imablance in baterial homeostasis at the nasophaynx, with impairment in respiratory microbiota. • The modulatory effect of target transnasal bacteriotheray by means of S. salivarius has been considered in children with chronic adenoiditis in children with recurrent acute otitis media with preliminary positive results.

What Is New: • This randomized controlled study, specifically designed on a cohrt of children with chronic adenoiditis, documents a certain effectiveness of the probiotic treatment in achieving a reduction in the grade of adenoidal hypertropy, compared to placebo.

Citing Articles

Antibiofilm Effects of Novel Compounds in Otitis Media Treatment: Systematic Review.

Jotic A, Savic Vujovic K, Cirkovic A, Bozic D, Brkic S, Subotic N Int J Mol Sci. 2024; 25(23).

PMID: 39684553 PMC: 11641745. DOI: 10.3390/ijms252312841.

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