Family Characteristics, Phylogenetic Reconstruction, and Potential Applications of the Plant BAHD Acyltransferase Family

Overview

Journal Front Plant Sci

Date 2023 Oct 23

PMID 37868312

Authors

Donghuan Xu

Zhong Wang

Weibing Zhuang

Tao Wang

Yinfeng Xie

Affiliations

Soon will be listed here.

Abstract

The BAHD acyltransferase family is a class of proteins in plants that can acylate a variety of primary and specialized secondary metabolites. The typically acylated products have greatly improved stability, lipid solubility, and bioavailability and thus show significant differences in their physicochemical properties and pharmacological activities. Here, we review the protein structure, catalytic mechanism, and phylogenetic reconstruction of plant BAHD acyltransferases to describe their family characteristics, acylation reactions, and the processes of potential functional differentiation. Moreover, the potential applications of the BAHD family in human activities are discussed from the perspectives of improving the quality of economic plants, enhancing the efficacy of medicinal plants, improving plant biomass for use in biofuel, and promoting stress resistance of land plants. This review provides a reference for the research and production of plant BAHD acyltransferases.

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References

Hampel D, Mau C, Croteau R . Taxol biosynthesis: Identification and characterization of two acetyl CoA:taxoid-O-acetyl transferases that divert pathway flux away from Taxol production. Arch Biochem Biophys. 2009; 487(2):91-7. PMC: 2748654. DOI: 10.1016/j.abb.2009.05.018. View

Eudes A, Mouille M, Robinson D, Benites V, Wang G, Roux L . Exploiting members of the BAHD acyltransferase family to synthesize multiple hydroxycinnamate and benzoate conjugates in yeast. Microb Cell Fact. 2016; 15(1):198. PMC: 5117604. DOI: 10.1186/s12934-016-0593-5. View

Zhang Y, Butelli E, Martin C . Engineering anthocyanin biosynthesis in plants. Curr Opin Plant Biol. 2014; 19:81-90. DOI: 10.1016/j.pbi.2014.05.011. View

Morales-Quintana L, Moya-Leon M, Herrera R . Computational study enlightens the structural role of the alcohol acyltransferase DFGWG motif. J Mol Model. 2015; 21(8):216. DOI: 10.1007/s00894-015-2762-6. View

de Souza W, Pacheco T, Duarte K, Sampaio B, Abrao de Oliveira Molinari P, Martins P . Silencing of a BAHD acyltransferase in sugarcane increases biomass digestibility. Biotechnol Biofuels. 2019; 12:111. PMC: 6501328. DOI: 10.1186/s13068-019-1450-7. View

Wilkerson C, Mansfield S, Lu F, Withers S, Park J, Karlen S . Monolignol ferulate transferase introduces chemically labile linkages into the lignin backbone. Science. 2014; 344(6179):90-3. DOI: 10.1126/science.1250161. View

Yan X, Qin X, Li W, Liang D, Qiao J, Li Y . Functional characterization and catalytic activity improvement of BAHD acyltransferase from Celastrus angulatus Maxim. Planta. 2020; 252(1):6. DOI: 10.1007/s00425-020-03413-2. View

Haslam T, Gerelle W, Graham S, Kunst L . The Unique Role of the ECERIFERUM2-LIKE Clade of the BAHD Acyltransferase Superfamily in Cuticular Wax Metabolism. Plants (Basel). 2017; 6(2). PMC: 5489795. DOI: 10.3390/plants6020023. View

Moghe G, Kruse L, Petersen M, Scossa F, Fernie A, Gaquerel E . BAHD Company: The Ever-Expanding Roles of the BAHD Acyltransferase Gene Family in Plants. Annu Rev Plant Biol. 2022; 74:165-194. DOI: 10.1146/annurev-arplant-062922-050122. View

10.

Tohge T, Wendenburg R, Ishihara H, Nakabayashi R, Watanabe M, Sulpice R . Characterization of a recently evolved flavonol-phenylacyltransferase gene provides signatures of natural light selection in Brassicaceae. Nat Commun. 2016; 7:12399. PMC: 4996938. DOI: 10.1038/ncomms12399. View

11.

DAuria J . Acyltransferases in plants: a good time to be BAHD. Curr Opin Plant Biol. 2006; 9(3):331-40. DOI: 10.1016/j.pbi.2006.03.016. View

12.

Unno H, Ichimaida F, Suzuki H, Takahashi S, Tanaka Y, Saito A . Structural and mutational studies of anthocyanin malonyltransferases establish the features of BAHD enzyme catalysis. J Biol Chem. 2007; 282(21):15812-22. DOI: 10.1074/jbc.M700638200. View

13.

Roumani M, Besseau S, Gagneul D, Robin C, Larbat R . Phenolamides in plants: an update on their function, regulation, and origin of their biosynthetic enzymes. J Exp Bot. 2020; 72(7):2334-2355. DOI: 10.1093/jxb/eraa582. View

14.

Li D, Xu Y, Xu G, Gu L, Li D, Shu H . Molecular cloning and expression of a gene encoding alcohol acyltransferase (MdAAT2) from apple (cv. Golden Delicious). Phytochemistry. 2006; 67(7):658-67. DOI: 10.1016/j.phytochem.2006.01.027. View

15.

Zhou W, Kong W, Yang C, Feng R, Xi W . Alcohol Acyltransferase Is Involved in the Biosynthesis of C6 Esters in Apricot ( L.) Fruit. Front Plant Sci. 2021; 12:763139. PMC: 8636060. DOI: 10.3389/fpls.2021.763139. View

16.

Chang A, Hu Z, Chen B, Vanderschuren H, Chen M, Qu Y . Characterization of trichome-specific BAHD acyltransferases involved in acylsugar biosynthesis in Nicotiana tabacum. J Exp Bot. 2022; 73(12):3913-3928. DOI: 10.1093/jxb/erac095. View

17.

Chiang Y, Levsh O, Lam C, Weng J, Wang Y . Structural and dynamic basis of substrate permissiveness in hydroxycinnamoyltransferase (HCT). PLoS Comput Biol. 2018; 14(10):e1006511. PMC: 6203249. DOI: 10.1371/journal.pcbi.1006511. View

18.

Moglia A, Lanteri S, Comino C, Hill L, Knevitt D, Cagliero C . Dual catalytic activity of hydroxycinnamoyl-coenzyme A quinate transferase from tomato allows it to moonlight in the synthesis of both mono- and dicaffeoylquinic acids. Plant Physiol. 2014; 166(4):1777-87. PMC: 4256858. DOI: 10.1104/pp.114.251371. View

19.

Tuominen L, Johnson V, Tsai C . Differential phylogenetic expansions in BAHD acyltransferases across five angiosperm taxa and evidence of divergent expression among Populus paralogues. BMC Genomics. 2011; 12:236. PMC: 3123328. DOI: 10.1186/1471-2164-12-236. View

20.

Liu X, Dai S, Zhou Y, Liu J, Li D, Zhang J . Crystal structure of the plant feruloyl-coenzyme A monolignol transferase provides insights into the formation of monolignol ferulate conjugates. Biochem Biophys Res Commun. 2022; 594:8-14. DOI: 10.1016/j.bbrc.2022.01.037. View