Hematopoietic Stem Cells Through the Ages: A Lifetime of Adaptation to Organismal Demands

Overview

Journal Cell Stem Cell

Publisher Cell Press

Specialty Cell Biology

Date 2023 Oct 21

PMID 37865087

Authors

Monica Kasbekar

Carl A Mitchell

Melissa A Proven

Emmanuelle Passegue

Affiliations

Soon will be listed here.

Abstract

Hematopoietic stem cells (HSCs), which govern the production of all blood lineages, transition through a series of functional states characterized by expansion during fetal development, functional quiescence in adulthood, and decline upon aging. We describe central features of HSC regulation during ontogeny to contextualize how adaptive responses over the life of the organism ultimately form the basis for HSC functional degradation with age. We particularly focus on the role of cell cycle regulation, inflammatory response pathways, epigenetic changes, and metabolic regulation. We then explore how the knowledge of age-related changes in HSC regulation can inform strategies for the rejuvenation of old HSCs.

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