Association of Cytomegalovirus (CMV) DNAemia With Long-Term Mortality in a Randomized Trial of Preemptive Therapy and Antiviral Prophylaxis for Prevention of CMV Disease in High-Risk Donor Seropositive, Recipient Seronegative Liver Transplant...

Overview

Journal Clin Infect Dis

Publisher Oxford University Press

Specialty Infectious Diseases

Date 2023 Oct 20

PMID 37862162

Authors

Lakshin Kumar

Sayan Dasgupta

Cristina Murray-Krezan

Nina Singh

Robert M Rakita

Cynthia E Fisher

Ajit P Limaye

Affiliations

Soon will be listed here.

Abstract

In a post-hoc analysis of the association of CMV DNAemia with long-term mortality in a randomized trial of CMV preemptive therapy vs. antiviral prophylaxis in D+R- liver transplant recipients, post-intervention CMV DNAemia was associated with increased mortality after adjusting for study arm.

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References

Spinner M, Saab G, Casabar E, Bowman L, Storch G, Brennan D . Impact of prophylactic versus preemptive valganciclovir on long-term renal allograft outcomes. Transplantation. 2010; 90(4):412-8. PMC: 2924927. DOI: 10.1097/TP.0b013e3181e81afc. View

Hunt P, Lee S, Siedner M . Immunologic Biomarkers, Morbidity, and Mortality in Treated HIV Infection. J Infect Dis. 2016; 214 Suppl 2:S44-50. PMC: 5021241. DOI: 10.1093/infdis/jiw275. View

Pickering H, Sen S, Arakawa-Hoyt J, Ishiyama K, Sun Y, Parmar R . NK and CD8+ T cell phenotypes predict onset and control of CMV viremia after kidney transplant. JCI Insight. 2021; 6(21). PMC: 8663544. DOI: 10.1172/jci.insight.153175. View

Singh N, Winston D, Razonable R, Lyon G, Silveira F, Wagener M . Effect of Preemptive Therapy vs Antiviral Prophylaxis on Cytomegalovirus Disease in Seronegative Liver Transplant Recipients With Seropositive Donors: A Randomized Clinical Trial. JAMA. 2020; 323(14):1378-1387. PMC: 7157180. DOI: 10.1001/jama.2020.3138. View

Mumtaz K, Faisal N, Husain S, Morillo A, Renner E, Shah P . Universal prophylaxis or preemptive strategy for cytomegalovirus disease after liver transplantation: a systematic review and meta-analysis. Am J Transplant. 2014; 15(2):472-81. DOI: 10.1111/ajt.13044. View

Selvey L, Lim W, Boan P, Swaminathan R, Slimings C, Harrison A . Cytomegalovirus viraemia and mortality in renal transplant recipients in the era of antiviral prophylaxis. Lessons from the western Australian experience. BMC Infect Dis. 2017; 17(1):501. PMC: 5514475. DOI: 10.1186/s12879-017-2599-y. View

Smith J, Corey L, Bittner R, Finn L, Healey P, Davis C . Subclinical viremia increases risk for chronic allograft injury in pediatric renal transplantation. J Am Soc Nephrol. 2010; 21(9):1579-86. PMC: 3013517. DOI: 10.1681/ASN.2009111188. View

Austin P, Latouche A, Fine J . A review of the use of time-varying covariates in the Fine-Gray subdistribution hazard competing risk regression model. Stat Med. 2019; 39(2):103-113. PMC: 6916372. DOI: 10.1002/sim.8399. View

Green M, Leisenring W, Xie H, Mast T, Cui Y, Sandmaier B . Cytomegalovirus viral load and mortality after haemopoietic stem cell transplantation in the era of pre-emptive therapy: a retrospective cohort study. Lancet Haematol. 2016; 3(3):e119-27. PMC: 4914379. DOI: 10.1016/S2352-3026(15)00289-6. View

10.

Zhang Z, Reinikainen J, Adeleke K, Pieterse M, Groothuis-Oudshoorn C . Time-varying covariates and coefficients in Cox regression models. Ann Transl Med. 2018; 6(7):121. PMC: 6015946. DOI: 10.21037/atm.2018.02.12. View

11.

Yadav D, Adhikari V, Yadav R, Singh A, Huang X, Zhang Q . Antiviral prophylaxis or preemptive therapy for cytomegalovirus after liver transplantation?: A systematic review and meta-analysis. Front Immunol. 2022; 13:953210. PMC: 9685424. DOI: 10.3389/fimmu.2022.953210. View